Cardiac mechanics are impaired during fatiguing exercise and cold pressor test in healthy older adults

Matthew D. Muller, Jessica L. Mast, Hardikkumar Patel, Lawrence I. Sinoway

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The use of TDI to quantify LV systolic and diastolic function is becoming more popular in clinical care as well as in physiological experiments. Our data indicate that Sm and Em are reduced in healthy older adults during IFHG and CPT. Furthermore, greater pressor responses to these laboratory stressors were associated with larger decrements in myocardial systolic and diastolic function in the older adults. Taken together, suboptimal LV adaptations to SNS stress may partly explain why acute heavy exertion (i.e., acute increases in afterload and myocardial O2 demand in the face of a sympathetic "brake" on the coronary vasculature) can trigger myocardial ischemia in certain individuals (44). Future studies evaluating the effects of healthy aging and aerobic exercise training on LV function during sympathetic stress are much needed.

Original languageEnglish (US)
Pages (from-to)186-194
Number of pages9
JournalJournal of applied physiology
Volume114
Issue number2
DOIs
StatePublished - Jan 15 2013

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Cardiac mechanics are impaired during fatiguing exercise and cold pressor test in healthy older adults'. Together they form a unique fingerprint.

  • Cite this