Cardiac transplant outcome of patients supported on left ventricular assist device vs intravenous inotropic therapy

Brian E. Jaski, Joseph C. Kim, David C. Naftel, John Jarcho, Maria Rosa Costanzo, Howard Eisen, James K. Kirklin, Robert C. Bourge

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background: Although the left ventricular assist device (LVAD) has been increasingly used as a bridge to transplant, its effect on post-transplant outcome is uncertain. We, therefore, designed this study using the Cardiac Transplant Research Database to compare patients supported on an LVAD before transplant with those treated with intravenous inotropic medical therapy. Methods and results: Of the 5,880 patients transplanted between 1990 and 1997, a total of 502 received support from LVADs and 2,514 received intravenous inotropic medical therapy at the time of transplant. Kaplan-Meier analysis showed no significant difference in post-transplant survival between the LVAD and medical-therapy groups (p = 0.09). Results of a multivariate Cox regression analysis were consistent with that of the Kaplan-Meier analysis and did not identify LVAD as a significant risk factor for mortality. The percentage of patients who received LVADs as a function of total transplants increased from 2% in 1990 to 16% in 1997. Furthermore, although the number of extracorporeal LVADs remained relatively constant, the number of intracorporeal LVADs increased over time. Multivariate parametric analysis found that the risk factors for post-transplant death in the LVAD group were extracorporeal LVAD use (p = 0.0004), elevated serum creatinine (p = 0.05), older donor age (p = 0.03), increased donor ischemic time (p < 0.0001), and earlier year of transplant (p = 0.03). Conclusions: Given a limited donor supply, the intracorporeal LVAD helps the sickest patients survive to transplant and provides post-transplant outcome similar to that of patients supported on inotropic medical therapy. Therefore, patients supported on LVADs before transplant may receive the greatest marginal benefit when compared with other transplant candidates.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume20
Issue number4
DOIs
StatePublished - Apr 25 2001

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Heart-Assist Devices
Transplants
Therapeutics
Kaplan-Meier Estimate
Tissue Donors
Group Psychotherapy
Creatinine
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Jaski, Brian E. ; Kim, Joseph C. ; Naftel, David C. ; Jarcho, John ; Costanzo, Maria Rosa ; Eisen, Howard ; Kirklin, James K. ; Bourge, Robert C. / Cardiac transplant outcome of patients supported on left ventricular assist device vs intravenous inotropic therapy. In: Journal of Heart and Lung Transplantation. 2001 ; Vol. 20, No. 4. pp. 449-456.
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Cardiac transplant outcome of patients supported on left ventricular assist device vs intravenous inotropic therapy. / Jaski, Brian E.; Kim, Joseph C.; Naftel, David C.; Jarcho, John; Costanzo, Maria Rosa; Eisen, Howard; Kirklin, James K.; Bourge, Robert C.

In: Journal of Heart and Lung Transplantation, Vol. 20, No. 4, 25.04.2001, p. 449-456.

Research output: Contribution to journalArticle

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T1 - Cardiac transplant outcome of patients supported on left ventricular assist device vs intravenous inotropic therapy

AU - Jaski, Brian E.

AU - Kim, Joseph C.

AU - Naftel, David C.

AU - Jarcho, John

AU - Costanzo, Maria Rosa

AU - Eisen, Howard

AU - Kirklin, James K.

AU - Bourge, Robert C.

PY - 2001/4/25

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N2 - Background: Although the left ventricular assist device (LVAD) has been increasingly used as a bridge to transplant, its effect on post-transplant outcome is uncertain. We, therefore, designed this study using the Cardiac Transplant Research Database to compare patients supported on an LVAD before transplant with those treated with intravenous inotropic medical therapy. Methods and results: Of the 5,880 patients transplanted between 1990 and 1997, a total of 502 received support from LVADs and 2,514 received intravenous inotropic medical therapy at the time of transplant. Kaplan-Meier analysis showed no significant difference in post-transplant survival between the LVAD and medical-therapy groups (p = 0.09). Results of a multivariate Cox regression analysis were consistent with that of the Kaplan-Meier analysis and did not identify LVAD as a significant risk factor for mortality. The percentage of patients who received LVADs as a function of total transplants increased from 2% in 1990 to 16% in 1997. Furthermore, although the number of extracorporeal LVADs remained relatively constant, the number of intracorporeal LVADs increased over time. Multivariate parametric analysis found that the risk factors for post-transplant death in the LVAD group were extracorporeal LVAD use (p = 0.0004), elevated serum creatinine (p = 0.05), older donor age (p = 0.03), increased donor ischemic time (p < 0.0001), and earlier year of transplant (p = 0.03). Conclusions: Given a limited donor supply, the intracorporeal LVAD helps the sickest patients survive to transplant and provides post-transplant outcome similar to that of patients supported on inotropic medical therapy. Therefore, patients supported on LVADs before transplant may receive the greatest marginal benefit when compared with other transplant candidates.

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