Cardiocirculatory adjustments to exercise following myocardial infarction in rats

H. Drexler, St F. Flaim, E. J. Toggart, M. R. Glick, Robert Zelis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The sequential changes of the cardiocirculatory response to exercise over time in rats with myocardial infarction and failure were studied. Hemodynamics and regional blood flow (RBF, radioactive microspheres) were determined at rest and during exercise either at 1, 10 or 42 days after infarction (MI, infarct size 41.4±2.6% of LV) or sham procedures (SH). Whereas the response to exercise was attenuated one day after surgery in MI and SH, cardiocirculatory recovery was present in SH at 10 days and LV systolic and end-diastolic pressures separated SH and MI groups. Renal vasoconstriction during exercise occurred 10 days after MI and BF to working muscle during exercise was significantly lower in MI as compared to SH. At 42 days after MI manifest heart failure was present and despite significant blood flow redistribution (p<0.05 MI vs SH in renal and cutaneous beds) impaired skeletal muscle flow was observed along with increased vascular resistance in working muscle during exercise. We conclude that the cardiocirculatory response to exercise following large MI follows a distinctive time-dependent pattern, which differs from that observed at rest. Besides exaggerated sympathetically mediated vasoconstriction during exercise, impaired vasodilatation in skeletal muscle at exercise emerged.

Original languageEnglish (US)
Pages (from-to)350-360
Number of pages11
JournalBasic Research in Cardiology
Volume81
Issue number4
DOIs
StatePublished - Jul 1 1986

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Vasoconstriction
Skeletal Muscle
Heart Failure
Myocardial Infarction
Kidney
Muscles
Regional Blood Flow
Ambulatory Surgical Procedures
Microspheres
Vasodilation
Vascular Resistance
Infarction
Hemodynamics
Blood Pressure
Skin

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Drexler, H. ; Flaim, St F. ; Toggart, E. J. ; Glick, M. R. ; Zelis, Robert. / Cardiocirculatory adjustments to exercise following myocardial infarction in rats. In: Basic Research in Cardiology. 1986 ; Vol. 81, No. 4. pp. 350-360.
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Cardiocirculatory adjustments to exercise following myocardial infarction in rats. / Drexler, H.; Flaim, St F.; Toggart, E. J.; Glick, M. R.; Zelis, Robert.

In: Basic Research in Cardiology, Vol. 81, No. 4, 01.07.1986, p. 350-360.

Research output: Contribution to journalArticle

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