Cardiorenal syndrome type 5: Clinical presentation, pathophysiology and management strategies from the eleventh consensus conference of the acute dialysis quality initiative (ADQI)

Ravindra L. Mehta, Hamid Rabb, Andrew D. Shaw, Kai Singbartl, Claudio Ronco, Peter A. McCullough, John A. Kellum

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

Cardiorenal syndrome type 5 (CRS-5) includes conditions where there is a simultaneous involvement of the heart and kidney from a systemic disorder. Given the wide spectrum of diseases that contribute to CRS-5, several pathophysiological mechanisms are invoked representing the response of the heart and kidney to the contributing disorder that is ongoing. The nature, duration and the underlying condition of the heart and kidney strongly influence the clinical course of CRS-5. In this paper we discuss the pathophysiology of CRS-5 in the setting of sepsis as a model system for CRS-5 providing a brief overview of strategies for monitoring and therapeutic intervention. We offer a framework for reference for considering other disorders leading to CRS-5 where the development of cardiac and renal dysfunction is more insidious.

Original languageEnglish (US)
Title of host publicationADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes
Pages174-194
Number of pages21
DOIs
StatePublished - 2013

Publication series

NameContributions to Nephrology
Volume182
ISSN (Print)0302-5144

All Science Journal Classification (ASJC) codes

  • Nephrology

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