Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats

L. Britt Wilson, P. Tim Wall, James Anthony Pawelczyk, Kanji Matsukawa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

This study examined the cardiovascular, ventilatory, and phrenic nerve responses to graded activation of mechanically sensitive muscle afferents. Using eight α-chloralose anesthetized cats, the left and right triceps surae muscles were stretched individually and simultaneously at progressive increments (0.5, 1.0, 1.5, 1.75 cm). Muscle stretch elicited sustained increases in mean arterial blood pressure (MAP) and heart rate (HR). These changes were related to the degree of stretch, as stretching one muscle 0.5 cm increased MAP 5 ± 2 mmHg and HR 7 ± 2 beats/min, while stretching both legs (1.75 cm) increased these variables 40 ± 11 mmHg and 11 ± 3 beats/min. By contrast, muscle stretch initially decreased ventilation and phrenic nerve activity. After the initial fall, ventilation, but not tidal phrenic activity, increased above baseline. These results show that a divergence exists between the initial cardiovascular and ventilatory responses to activation of mechanically sensitive muscle afferents. Further, the hypernea elicited by muscle stretch in spontaneously breathing anesthetized cats appears to be the result of excitation of non-diaphragmatic muscles of ventilation.

Original languageEnglish (US)
Pages (from-to)251-266
Number of pages16
JournalRespiration Physiology
Volume98
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Phrenic Nerve
Cats
Muscles
Arterial Pressure
Ventilation
Heart Rate
Chloralose
Diaphragm
Leg
Respiration

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Wilson, L. Britt ; Wall, P. Tim ; Pawelczyk, James Anthony ; Matsukawa, Kanji. / Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats. In: Respiration Physiology. 1994 ; Vol. 98, No. 3. pp. 251-266.
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Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats. / Wilson, L. Britt; Wall, P. Tim; Pawelczyk, James Anthony; Matsukawa, Kanji.

In: Respiration Physiology, Vol. 98, No. 3, 01.01.1994, p. 251-266.

Research output: Contribution to journalArticle

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