Cardiovascular and catecholamine responses to static exercise in partially curarized humans

James Anthony Pawelczyk, R. A. Pawelczyk, J. Warberg, J. H. Mitchell, N. H. Secher

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Neural control of the circulation was evaluated during static exercise in 19 subjects by the determination of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO) and plasma catecholamines. Influence from central command was evaluated during contractions with weakened muscles following partial curarization and reflex influence from metaboreceptors was assessed by post-exercise muscle ischaemia. Static handgrip increased HR and more so MAP and CO and MAP remained elevated during post-exercise muscle ischaemia. With partial curarization plasma catecholamines were also increased (P < 0.05). Two-leg extension increased all variables and during post-exercise muscle ischaemia elevations of HR, MAP and CO were maintained (P < 0.05). With partial curarization HR, MAP and plasma noradrenaline were even greater during the contraction. With the involvement of both legs during static exercise, reflex influence from the muscles elevated blood pressure by way of HR and CO and the importance of central command was detectable for HR and MAP as plasma catecholamines became elevated. However, the results indicate a separation between a central command influence on HR and CO related to an increase in plasma catecholamines during a handgrip, while the reflex influence an blood pressure was directed towards total peripheral resistance.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalActa Physiologica Scandinavica
Volume160
Issue number1
DOIs
StatePublished - Jan 1 1997

Fingerprint

Catecholamines
Arterial Pressure
Cardiac Output
Heart Rate
Muscles
Reflex
Ischemia
Leg
Blood Pressure
Vascular Resistance
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Pawelczyk, James Anthony ; Pawelczyk, R. A. ; Warberg, J. ; Mitchell, J. H. ; Secher, N. H. / Cardiovascular and catecholamine responses to static exercise in partially curarized humans. In: Acta Physiologica Scandinavica. 1997 ; Vol. 160, No. 1. pp. 23-28.
@article{8022f0546fa5408fa2cac5bbab5e49fe,
title = "Cardiovascular and catecholamine responses to static exercise in partially curarized humans",
abstract = "Neural control of the circulation was evaluated during static exercise in 19 subjects by the determination of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO) and plasma catecholamines. Influence from central command was evaluated during contractions with weakened muscles following partial curarization and reflex influence from metaboreceptors was assessed by post-exercise muscle ischaemia. Static handgrip increased HR and more so MAP and CO and MAP remained elevated during post-exercise muscle ischaemia. With partial curarization plasma catecholamines were also increased (P < 0.05). Two-leg extension increased all variables and during post-exercise muscle ischaemia elevations of HR, MAP and CO were maintained (P < 0.05). With partial curarization HR, MAP and plasma noradrenaline were even greater during the contraction. With the involvement of both legs during static exercise, reflex influence from the muscles elevated blood pressure by way of HR and CO and the importance of central command was detectable for HR and MAP as plasma catecholamines became elevated. However, the results indicate a separation between a central command influence on HR and CO related to an increase in plasma catecholamines during a handgrip, while the reflex influence an blood pressure was directed towards total peripheral resistance.",
author = "Pawelczyk, {James Anthony} and Pawelczyk, {R. A.} and J. Warberg and Mitchell, {J. H.} and Secher, {N. H.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1046/j.1365-201X.1997.00115.x",
language = "English (US)",
volume = "160",
pages = "23--28",
journal = "Skandinavisches Archiv F{\"u}r Physiologie",
issn = "0370-839X",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

Cardiovascular and catecholamine responses to static exercise in partially curarized humans. / Pawelczyk, James Anthony; Pawelczyk, R. A.; Warberg, J.; Mitchell, J. H.; Secher, N. H.

In: Acta Physiologica Scandinavica, Vol. 160, No. 1, 01.01.1997, p. 23-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular and catecholamine responses to static exercise in partially curarized humans

AU - Pawelczyk, James Anthony

AU - Pawelczyk, R. A.

AU - Warberg, J.

AU - Mitchell, J. H.

AU - Secher, N. H.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Neural control of the circulation was evaluated during static exercise in 19 subjects by the determination of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO) and plasma catecholamines. Influence from central command was evaluated during contractions with weakened muscles following partial curarization and reflex influence from metaboreceptors was assessed by post-exercise muscle ischaemia. Static handgrip increased HR and more so MAP and CO and MAP remained elevated during post-exercise muscle ischaemia. With partial curarization plasma catecholamines were also increased (P < 0.05). Two-leg extension increased all variables and during post-exercise muscle ischaemia elevations of HR, MAP and CO were maintained (P < 0.05). With partial curarization HR, MAP and plasma noradrenaline were even greater during the contraction. With the involvement of both legs during static exercise, reflex influence from the muscles elevated blood pressure by way of HR and CO and the importance of central command was detectable for HR and MAP as plasma catecholamines became elevated. However, the results indicate a separation between a central command influence on HR and CO related to an increase in plasma catecholamines during a handgrip, while the reflex influence an blood pressure was directed towards total peripheral resistance.

AB - Neural control of the circulation was evaluated during static exercise in 19 subjects by the determination of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO) and plasma catecholamines. Influence from central command was evaluated during contractions with weakened muscles following partial curarization and reflex influence from metaboreceptors was assessed by post-exercise muscle ischaemia. Static handgrip increased HR and more so MAP and CO and MAP remained elevated during post-exercise muscle ischaemia. With partial curarization plasma catecholamines were also increased (P < 0.05). Two-leg extension increased all variables and during post-exercise muscle ischaemia elevations of HR, MAP and CO were maintained (P < 0.05). With partial curarization HR, MAP and plasma noradrenaline were even greater during the contraction. With the involvement of both legs during static exercise, reflex influence from the muscles elevated blood pressure by way of HR and CO and the importance of central command was detectable for HR and MAP as plasma catecholamines became elevated. However, the results indicate a separation between a central command influence on HR and CO related to an increase in plasma catecholamines during a handgrip, while the reflex influence an blood pressure was directed towards total peripheral resistance.

UR - http://www.scopus.com/inward/record.url?scp=0030906926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030906926&partnerID=8YFLogxK

U2 - 10.1046/j.1365-201X.1997.00115.x

DO - 10.1046/j.1365-201X.1997.00115.x

M3 - Article

C2 - 9179307

AN - SCOPUS:0030906926

VL - 160

SP - 23

EP - 28

JO - Skandinavisches Archiv Für Physiologie

JF - Skandinavisches Archiv Für Physiologie

SN - 0370-839X

IS - 1

ER -