Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders

Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Store-operated Ca2+ entry (SOCE) mediated by STIM and Orai proteins is a highly regulated and ubiquitous signaling pathway that plays an important role in various cellular and physiological functions. Endoplasmic reticulum (ER) serves as the major site for intracellular Ca2+ storage. Stromal Interaction Molecule 1/2 (STIM1/2) sense decrease in ER Ca2+ levels and transmits the message to plasma membrane Ca2+ channels constituted by Orai family members (Orai1/2/3) resulting in Ca2+ influx into the cells. This increase in cytosolic Ca2+ in turn activates a variety of signaling cascades to regulate a plethora of cellular functions. Evidence from the literature suggests that SOCE dysregulation is associated with several pathophysiologies, including vascular disorders. Interestingly, recent studies have suggested that STIM proteins may also regulate vascular functions independent of their contribution to SOCE. In this updated book chapter, we will focus on the physiological role of STIM and Orai proteins in the vasculature (endothelial cells and vascular smooth muscle cells). We will further retrospect the literature implicating a critical role for these proteins in vascular disease.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages425-452
Number of pages28
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume993
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Hemostatic Disorders
Hemostatics
Blood Vessels
Endoplasmic Reticulum
Proteins
Endothelial cells
Cell membranes
Ion Channels
Vascular Diseases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Endothelial Cells
Cells
Cell Membrane
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tanwar, J., Trebak, M., & Motiani, R. K. (2017). Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders. In Advances in Experimental Medicine and Biology (pp. 425-452). (Advances in Experimental Medicine and Biology; Vol. 993). Springer New York LLC. https://doi.org/10.1007/978-3-319-57732-6_22
Tanwar, Jyoti ; Trebak, Mohamed ; Motiani, Rajender K. / Cardiovascular and hemostatic disorders : Role of STIM and orai proteins in vascular Disorders. Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. pp. 425-452 (Advances in Experimental Medicine and Biology).
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Tanwar, J, Trebak, M & Motiani, RK 2017, Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 993, Springer New York LLC, pp. 425-452. https://doi.org/10.1007/978-3-319-57732-6_22

Cardiovascular and hemostatic disorders : Role of STIM and orai proteins in vascular Disorders. / Tanwar, Jyoti; Trebak, Mohamed; Motiani, Rajender K.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 425-452 (Advances in Experimental Medicine and Biology; Vol. 993).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Tanwar J, Trebak M, Motiani RK. Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2017. p. 425-452. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-57732-6_22