TY - JOUR
T1 - CARMing down the SINEs of anarchy
T2 - Two paths to freedom from paraspeckle detention
AU - Elbarbary, Reyad A.
AU - Maquat, Lynne E.
N1 - Publisher Copyright:
© 2015 Elbarbary and Maquat.
PY - 2015
Y1 - 2015
N2 - A subset of messenger RNAs (mRNAs) that contain inverted Alu elements in their 3′ untranslated region are inefficiently exported to the cytoplasm and retained in subnuclear bodies called paraspeckles. The arginine methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1) promotes the nuclear export of these mRNAs by methylating the paraspeckle component p54nrb, which reduces the binding of p54nrb to the inverted Alu elements, and down-regulating synthesis of another paraspeckle component, the long noncoding RNA NEAT1, which inhibits paraspeckle formation.
AB - A subset of messenger RNAs (mRNAs) that contain inverted Alu elements in their 3′ untranslated region are inefficiently exported to the cytoplasm and retained in subnuclear bodies called paraspeckles. The arginine methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1) promotes the nuclear export of these mRNAs by methylating the paraspeckle component p54nrb, which reduces the binding of p54nrb to the inverted Alu elements, and down-regulating synthesis of another paraspeckle component, the long noncoding RNA NEAT1, which inhibits paraspeckle formation.
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U2 - 10.1101/gad.261438.115
DO - 10.1101/gad.261438.115
M3 - Article
C2 - 25838539
AN - SCOPUS:84926375402
SN - 0890-9369
VL - 29
SP - 687
EP - 689
JO - Genes and Development
JF - Genes and Development
IS - 7
ER -