Carotene intake and the risk of laryngeal cancer in coastal Texas

Dorothy Mackerras, Patricia A. Buffler, D. Elizabeth Randall, Milton Z. Nichaman, Linda Williams Pickle, Thomas J. Mason

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Between 1978 and 1980, data were collected for a case-comparison study of laryngeal cancer in white males aged 30-79 years in six Texas counties using all histologically confirmed incident cases and a population-based comparison group. Dietary interviews were obtained from 151 living cases and 178 living comparison subjects. A significant inverse association (odds ratio (OR) = 2.1) was found between low carotene intake and the risk of laryngeal cancer, but no association was found with total vitamin A or retinol intake. The inverse association with carotene intake was strongest among those who had stopped smoking 2-10 years before (OR = 5.9). The same risk for vitamin A intake was found by using a short list of foods based on contribution to variation in intake as was found by using a longer list based on per cent contribution to total intake. Definition of carotene as that which comes only from plant sources gives an estimate similar to a more complex method that takes into account carotene derived from both plant and animal sources.

Original languageEnglish (US)
Pages (from-to)980-988
Number of pages9
JournalAmerican journal of epidemiology
Volume128
Issue number5
DOIs
StatePublished - Jan 1 1988

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Laryngeal Neoplasms
Carotenoids
Vitamin A
Odds Ratio
Case-Control Studies
Smoking
Interviews
Food
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Mackerras, D., Buffler, P. A., Randall, D. E., Nichaman, M. Z., Pickle, L. W., & Mason, T. J. (1988). Carotene intake and the risk of laryngeal cancer in coastal Texas. American journal of epidemiology, 128(5), 980-988. https://doi.org/10.1093/oxfordjournals.aje.a115071
Mackerras, Dorothy ; Buffler, Patricia A. ; Randall, D. Elizabeth ; Nichaman, Milton Z. ; Pickle, Linda Williams ; Mason, Thomas J. / Carotene intake and the risk of laryngeal cancer in coastal Texas. In: American journal of epidemiology. 1988 ; Vol. 128, No. 5. pp. 980-988.
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Mackerras, D, Buffler, PA, Randall, DE, Nichaman, MZ, Pickle, LW & Mason, TJ 1988, 'Carotene intake and the risk of laryngeal cancer in coastal Texas', American journal of epidemiology, vol. 128, no. 5, pp. 980-988. https://doi.org/10.1093/oxfordjournals.aje.a115071

Carotene intake and the risk of laryngeal cancer in coastal Texas. / Mackerras, Dorothy; Buffler, Patricia A.; Randall, D. Elizabeth; Nichaman, Milton Z.; Pickle, Linda Williams; Mason, Thomas J.

In: American journal of epidemiology, Vol. 128, No. 5, 01.01.1988, p. 980-988.

Research output: Contribution to journalArticle

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Mackerras D, Buffler PA, Randall DE, Nichaman MZ, Pickle LW, Mason TJ. Carotene intake and the risk of laryngeal cancer in coastal Texas. American journal of epidemiology. 1988 Jan 1;128(5):980-988. https://doi.org/10.1093/oxfordjournals.aje.a115071