Carotene intake and the risk of laryngeal cancer in coastal Texas

Dorothy Mackerras, Patricia A. Buffler, D. Elizabeth Randall, Milton Z. Nichaman, Linda W. Pickle, Thomas J. Mason

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Between 1978 and 1980, data were collected for a case-comparison study of laryngeal cancer in white males aged 30-79 years in six Texas counties using all histologically confirmed incident cases and a population-based comparison group. Dietary interviews were obtained from 151 living cases and 178 living comparison subjects. A significant inverse association (odds ratio (OR) = 2.1) was found between low carotene intake and the risk of laryngeal cancer, but no association was found with total vitamin A or retinol intake. The inverse association with carotene intake was strongest among those who had stopped smoking 2-10 years before (OR = 5.9). The same risk for vitamin A intake was found by using a short list of foods based on contribution to variation in intake as was found by using a longer list based on per cent contribution to total intake. Definition of carotene as that which comes only from plant sources gives an estimate similar to a more complex method that takes into account carotene derived from both plant and animal sources.

Original languageEnglish (US)
Pages (from-to)980-988
Number of pages9
JournalAmerican journal of epidemiology
Volume128
Issue number5
DOIs
StatePublished - Nov 1988

All Science Journal Classification (ASJC) codes

  • Epidemiology

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