Carotenoids, vitamin A, and estrogen receptorstatus in breast cancer

Cheryl L. Rock, Gordon A. Saxe, Mack Ruffin, David A. August, David Schottenfeld

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Among patients with breast cancer, tumors that contain estrogen receptors (ER) are associated with improved survival and better response to hormone therapy than those not expressing these receptors. The purpose of these case comparison studies was to examine the relationship between carotenoids, vitamin A, and the tumor ER status in women at diagnosis of primary breast cancer. The focus of the first study was the relationship between dietary intake and ER status, and the focus of the second study was the relationship between ER status and the plasma carotenoid, retinol, and tocopherol concentrations. We evaluated tumor ER status and self-reported dietary intake in 142 women and plasma concentrations of carotenoids, retinol, and tocopherols in 149 women, at diagnosis of breast cancer, before any medical or surgical treatment. In the first study the overall odds of ER-positive status were increased in relation to number of mammograms in the past five years, number of breast-fed babies, dietary carotenoid intake, and more frequent intake of yellow and green vegetables. Overall odds of ER-positive status were decreased in relation to years of oral contraceptive use and preformed vitamin A intake. In the second study older women, women with higher plasma lutein concentration, and women not using β-carotene supplements were more likely to be ER positive, when data were adjusted for body mass index and factors that may influence breast cancer risk or hormonal status. Significant independent relationships between plasma retinal or tocopherol concentrations and ER status were not observed. The strong and independent relationships between carotenoid intake, plasma lutein concentration, and ER status may relate to observations linking a carotenoid-rich diet with improved prognosis after diagnosis of breast cancer.

Original languageEnglish (US)
Pages (from-to)281-296
Number of pages16
JournalNutrition and cancer
Volume25
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Carotenoids
Vitamin A
Estrogen Receptors
Estrogens
Breast Neoplasms
Tocopherols
Lutein
Women's Rights
Oral Contraceptives
Vegetables
Case-Control Studies
Neoplasms
Breast
Body Mass Index
Hormones
Diet
Survival

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Rock, Cheryl L. ; Saxe, Gordon A. ; Ruffin, Mack ; August, David A. ; Schottenfeld, David. / Carotenoids, vitamin A, and estrogen receptorstatus in breast cancer. In: Nutrition and cancer. 1996 ; Vol. 25, No. 3. pp. 281-296.
@article{fc754b5fdb9f4248bdc6fc8d6fae0605,
title = "Carotenoids, vitamin A, and estrogen receptorstatus in breast cancer",
abstract = "Among patients with breast cancer, tumors that contain estrogen receptors (ER) are associated with improved survival and better response to hormone therapy than those not expressing these receptors. The purpose of these case comparison studies was to examine the relationship between carotenoids, vitamin A, and the tumor ER status in women at diagnosis of primary breast cancer. The focus of the first study was the relationship between dietary intake and ER status, and the focus of the second study was the relationship between ER status and the plasma carotenoid, retinol, and tocopherol concentrations. We evaluated tumor ER status and self-reported dietary intake in 142 women and plasma concentrations of carotenoids, retinol, and tocopherols in 149 women, at diagnosis of breast cancer, before any medical or surgical treatment. In the first study the overall odds of ER-positive status were increased in relation to number of mammograms in the past five years, number of breast-fed babies, dietary carotenoid intake, and more frequent intake of yellow and green vegetables. Overall odds of ER-positive status were decreased in relation to years of oral contraceptive use and preformed vitamin A intake. In the second study older women, women with higher plasma lutein concentration, and women not using β-carotene supplements were more likely to be ER positive, when data were adjusted for body mass index and factors that may influence breast cancer risk or hormonal status. Significant independent relationships between plasma retinal or tocopherol concentrations and ER status were not observed. The strong and independent relationships between carotenoid intake, plasma lutein concentration, and ER status may relate to observations linking a carotenoid-rich diet with improved prognosis after diagnosis of breast cancer.",
author = "Rock, {Cheryl L.} and Saxe, {Gordon A.} and Mack Ruffin and August, {David A.} and David Schottenfeld",
year = "1996",
month = "1",
day = "1",
doi = "10.1080/01635589609514452",
language = "English (US)",
volume = "25",
pages = "281--296",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Routledge",
number = "3",

}

Carotenoids, vitamin A, and estrogen receptorstatus in breast cancer. / Rock, Cheryl L.; Saxe, Gordon A.; Ruffin, Mack; August, David A.; Schottenfeld, David.

In: Nutrition and cancer, Vol. 25, No. 3, 01.01.1996, p. 281-296.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carotenoids, vitamin A, and estrogen receptorstatus in breast cancer

AU - Rock, Cheryl L.

AU - Saxe, Gordon A.

AU - Ruffin, Mack

AU - August, David A.

AU - Schottenfeld, David

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Among patients with breast cancer, tumors that contain estrogen receptors (ER) are associated with improved survival and better response to hormone therapy than those not expressing these receptors. The purpose of these case comparison studies was to examine the relationship between carotenoids, vitamin A, and the tumor ER status in women at diagnosis of primary breast cancer. The focus of the first study was the relationship between dietary intake and ER status, and the focus of the second study was the relationship between ER status and the plasma carotenoid, retinol, and tocopherol concentrations. We evaluated tumor ER status and self-reported dietary intake in 142 women and plasma concentrations of carotenoids, retinol, and tocopherols in 149 women, at diagnosis of breast cancer, before any medical or surgical treatment. In the first study the overall odds of ER-positive status were increased in relation to number of mammograms in the past five years, number of breast-fed babies, dietary carotenoid intake, and more frequent intake of yellow and green vegetables. Overall odds of ER-positive status were decreased in relation to years of oral contraceptive use and preformed vitamin A intake. In the second study older women, women with higher plasma lutein concentration, and women not using β-carotene supplements were more likely to be ER positive, when data were adjusted for body mass index and factors that may influence breast cancer risk or hormonal status. Significant independent relationships between plasma retinal or tocopherol concentrations and ER status were not observed. The strong and independent relationships between carotenoid intake, plasma lutein concentration, and ER status may relate to observations linking a carotenoid-rich diet with improved prognosis after diagnosis of breast cancer.

AB - Among patients with breast cancer, tumors that contain estrogen receptors (ER) are associated with improved survival and better response to hormone therapy than those not expressing these receptors. The purpose of these case comparison studies was to examine the relationship between carotenoids, vitamin A, and the tumor ER status in women at diagnosis of primary breast cancer. The focus of the first study was the relationship between dietary intake and ER status, and the focus of the second study was the relationship between ER status and the plasma carotenoid, retinol, and tocopherol concentrations. We evaluated tumor ER status and self-reported dietary intake in 142 women and plasma concentrations of carotenoids, retinol, and tocopherols in 149 women, at diagnosis of breast cancer, before any medical or surgical treatment. In the first study the overall odds of ER-positive status were increased in relation to number of mammograms in the past five years, number of breast-fed babies, dietary carotenoid intake, and more frequent intake of yellow and green vegetables. Overall odds of ER-positive status were decreased in relation to years of oral contraceptive use and preformed vitamin A intake. In the second study older women, women with higher plasma lutein concentration, and women not using β-carotene supplements were more likely to be ER positive, when data were adjusted for body mass index and factors that may influence breast cancer risk or hormonal status. Significant independent relationships between plasma retinal or tocopherol concentrations and ER status were not observed. The strong and independent relationships between carotenoid intake, plasma lutein concentration, and ER status may relate to observations linking a carotenoid-rich diet with improved prognosis after diagnosis of breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=0029938108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029938108&partnerID=8YFLogxK

U2 - 10.1080/01635589609514452

DO - 10.1080/01635589609514452

M3 - Article

C2 - 8771571

AN - SCOPUS:0029938108

VL - 25

SP - 281

EP - 296

JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

IS - 3

ER -