Carotid atherosclerosis, cerebrospinal fluid pressure, and retinal vessel diameters

The asymptomatic polyvascular abnormalities in community study

Jing Yan Yang, Xuan Yang, Yang Li, Jie Xu, Yong Zhou, An Xin Wang, Xiang Gao, Liang Xu, Shou Ling Wu, Wen Bin Wei, Xing Quan Zhao, Jost B. Jonas

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4 Citations (Scopus)

Abstract

Purpose: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44×Body Mass Index[kg/m2]+0.16×Diastolic Blood Pressure[mmHg]-0.18 × Age[Years]-1.91. Results: In multivariable analysis (goodness of fit r2:0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92;95% confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P<0.001; beta:0.18;B:0.35;95%CI:0.28,0.42), lower diastolic blood pressure (P<0.001;beta:-0.16;B:- 0.17;95%CI:-0.21,-0.3), younger age (P<0.001;beta:-0.08; B:-0.16;95%;CI:-0.25,-0.08), and less abdominal circumference (P = 0.003;beta:-0.06;B:-0.11;95%CI:-0.18,-0.03). Thicker retinal vein diameter was associated (r = 0.40) with higher estimated CSFP (P<0.001;beta:0.09;B:0.78;95%CI:0.47,1.08) after adjusting for wider retinal arteries (P<0.001;beta:0.27;B:0.36;95%CI:0.31,0.41), thicker retinal nerve fiber layer thickness (P = 0.03;beta:0.22;B:0.56;95%CI:0.46,0.65) and male gender (P<0.001;beta:-0.08;B:-3.98;95%CI:-5.88,2.09). Conclusions: Thinner retinal artery diameter was significantly, however weakly, associated with increased common carotid artery IMT. It suggests that retinal microvascular changes were only week indicators for an atherosclerotic carotid artery pathology. Thicker retinal vein diameter was associated with higher estimated CSFP, confirming associations between higher estimated CSFP and higher incidence of retinal vein occlusion.

Original languageEnglish (US)
Article numbere0166993
JournalPloS one
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2016

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Cerebrospinal Fluid Pressure
Cerebrospinal fluid
Retinal Vessels
Carotid Artery Diseases
cerebrospinal fluid
atherosclerosis
confidence interval
Confidence Intervals
carotid arteries
Retinal Artery
Blood pressure
Carotid Arteries
arteries
Retinal Vein
Carotid Intima-Media Thickness
Coal industry
Common Carotid Artery
nerve fibers
Fibers
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yang, Jing Yan ; Yang, Xuan ; Li, Yang ; Xu, Jie ; Zhou, Yong ; Wang, An Xin ; Gao, Xiang ; Xu, Liang ; Wu, Shou Ling ; Wei, Wen Bin ; Zhao, Xing Quan ; Jonas, Jost B. / Carotid atherosclerosis, cerebrospinal fluid pressure, and retinal vessel diameters : The asymptomatic polyvascular abnormalities in community study. In: PloS one. 2016 ; Vol. 11, No. 12.
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title = "Carotid atherosclerosis, cerebrospinal fluid pressure, and retinal vessel diameters: The asymptomatic polyvascular abnormalities in community study",
abstract = "Purpose: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44×Body Mass Index[kg/m2]+0.16×Diastolic Blood Pressure[mmHg]-0.18 × Age[Years]-1.91. Results: In multivariable analysis (goodness of fit r2:0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92;95{\%} confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P<0.001; beta:0.18;B:0.35;95{\%}CI:0.28,0.42), lower diastolic blood pressure (P<0.001;beta:-0.16;B:- 0.17;95{\%}CI:-0.21,-0.3), younger age (P<0.001;beta:-0.08; B:-0.16;95{\%};CI:-0.25,-0.08), and less abdominal circumference (P = 0.003;beta:-0.06;B:-0.11;95{\%}CI:-0.18,-0.03). Thicker retinal vein diameter was associated (r = 0.40) with higher estimated CSFP (P<0.001;beta:0.09;B:0.78;95{\%}CI:0.47,1.08) after adjusting for wider retinal arteries (P<0.001;beta:0.27;B:0.36;95{\%}CI:0.31,0.41), thicker retinal nerve fiber layer thickness (P = 0.03;beta:0.22;B:0.56;95{\%}CI:0.46,0.65) and male gender (P<0.001;beta:-0.08;B:-3.98;95{\%}CI:-5.88,2.09). Conclusions: Thinner retinal artery diameter was significantly, however weakly, associated with increased common carotid artery IMT. It suggests that retinal microvascular changes were only week indicators for an atherosclerotic carotid artery pathology. Thicker retinal vein diameter was associated with higher estimated CSFP, confirming associations between higher estimated CSFP and higher incidence of retinal vein occlusion.",
author = "Yang, {Jing Yan} and Xuan Yang and Yang Li and Jie Xu and Yong Zhou and Wang, {An Xin} and Xiang Gao and Liang Xu and Wu, {Shou Ling} and Wei, {Wen Bin} and Zhao, {Xing Quan} and Jonas, {Jost B.}",
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Carotid atherosclerosis, cerebrospinal fluid pressure, and retinal vessel diameters : The asymptomatic polyvascular abnormalities in community study. / Yang, Jing Yan; Yang, Xuan; Li, Yang; Xu, Jie; Zhou, Yong; Wang, An Xin; Gao, Xiang; Xu, Liang; Wu, Shou Ling; Wei, Wen Bin; Zhao, Xing Quan; Jonas, Jost B.

In: PloS one, Vol. 11, No. 12, e0166993, 01.12.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carotid atherosclerosis, cerebrospinal fluid pressure, and retinal vessel diameters

T2 - The asymptomatic polyvascular abnormalities in community study

AU - Yang, Jing Yan

AU - Yang, Xuan

AU - Li, Yang

AU - Xu, Jie

AU - Zhou, Yong

AU - Wang, An Xin

AU - Gao, Xiang

AU - Xu, Liang

AU - Wu, Shou Ling

AU - Wei, Wen Bin

AU - Zhao, Xing Quan

AU - Jonas, Jost B.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44×Body Mass Index[kg/m2]+0.16×Diastolic Blood Pressure[mmHg]-0.18 × Age[Years]-1.91. Results: In multivariable analysis (goodness of fit r2:0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92;95% confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P<0.001; beta:0.18;B:0.35;95%CI:0.28,0.42), lower diastolic blood pressure (P<0.001;beta:-0.16;B:- 0.17;95%CI:-0.21,-0.3), younger age (P<0.001;beta:-0.08; B:-0.16;95%;CI:-0.25,-0.08), and less abdominal circumference (P = 0.003;beta:-0.06;B:-0.11;95%CI:-0.18,-0.03). Thicker retinal vein diameter was associated (r = 0.40) with higher estimated CSFP (P<0.001;beta:0.09;B:0.78;95%CI:0.47,1.08) after adjusting for wider retinal arteries (P<0.001;beta:0.27;B:0.36;95%CI:0.31,0.41), thicker retinal nerve fiber layer thickness (P = 0.03;beta:0.22;B:0.56;95%CI:0.46,0.65) and male gender (P<0.001;beta:-0.08;B:-3.98;95%CI:-5.88,2.09). Conclusions: Thinner retinal artery diameter was significantly, however weakly, associated with increased common carotid artery IMT. It suggests that retinal microvascular changes were only week indicators for an atherosclerotic carotid artery pathology. Thicker retinal vein diameter was associated with higher estimated CSFP, confirming associations between higher estimated CSFP and higher incidence of retinal vein occlusion.

AB - Purpose: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44×Body Mass Index[kg/m2]+0.16×Diastolic Blood Pressure[mmHg]-0.18 × Age[Years]-1.91. Results: In multivariable analysis (goodness of fit r2:0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92;95% confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P<0.001; beta:0.18;B:0.35;95%CI:0.28,0.42), lower diastolic blood pressure (P<0.001;beta:-0.16;B:- 0.17;95%CI:-0.21,-0.3), younger age (P<0.001;beta:-0.08; B:-0.16;95%;CI:-0.25,-0.08), and less abdominal circumference (P = 0.003;beta:-0.06;B:-0.11;95%CI:-0.18,-0.03). Thicker retinal vein diameter was associated (r = 0.40) with higher estimated CSFP (P<0.001;beta:0.09;B:0.78;95%CI:0.47,1.08) after adjusting for wider retinal arteries (P<0.001;beta:0.27;B:0.36;95%CI:0.31,0.41), thicker retinal nerve fiber layer thickness (P = 0.03;beta:0.22;B:0.56;95%CI:0.46,0.65) and male gender (P<0.001;beta:-0.08;B:-3.98;95%CI:-5.88,2.09). Conclusions: Thinner retinal artery diameter was significantly, however weakly, associated with increased common carotid artery IMT. It suggests that retinal microvascular changes were only week indicators for an atherosclerotic carotid artery pathology. Thicker retinal vein diameter was associated with higher estimated CSFP, confirming associations between higher estimated CSFP and higher incidence of retinal vein occlusion.

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