Abstract
Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 457-466 |
| Number of pages | 10 |
| Journal | Current Reviews in Musculoskeletal Medicine |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2015 |
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All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
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Cartilage repair techniques in the knee : stem cell therapies. / Yoshiya, Shinichi; Dhawan, Aman.
In: Current Reviews in Musculoskeletal Medicine, Vol. 8, No. 4, 01.12.2015, p. 457-466.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Cartilage repair techniques in the knee
T2 - stem cell therapies
AU - Yoshiya, Shinichi
AU - Dhawan, Aman
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.
AB - Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.
UR - http://www.scopus.com/inward/record.url?scp=84946497085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946497085&partnerID=8YFLogxK
U2 - 10.1007/s12178-015-9302-y
DO - 10.1007/s12178-015-9302-y
M3 - Review article
C2 - 26373771
AN - SCOPUS:84946497085
VL - 8
SP - 457
EP - 466
JO - Current Reviews in Musculoskeletal Medicine
JF - Current Reviews in Musculoskeletal Medicine
SN - 1935-9748
IS - 4
ER -