Cartwright blood group system review

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Abstract

The Cartwright (Yt) blood group system consists of two antigens, Yta and Ytb, that result from point mutations in the acetylcholinesterase gene on chromosome 7q. Yta is a highincidence antigen, whereas its antithetical antigen, Ytb, shows much lower incidence. Anti-Yta and anti-Ytb are relatively rare. Anti-Yta is more commonly found in individuals of Jewish descent. Cartwright antibodies are rarely clinically significant; however, cases of in vivo hemolysis have been reported, suggesting that clinical significance should be interpreted on a case-by-case basis.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalImmunohematology
Volume28
Issue number2
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Hematology

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