Case-control study of diet and mesothelioma in louisiana

Mark H. Schiffman, Linda W. Pickle, Shelia Hoar Zahm, Roni Falk, Joseph F. Fraumeni, Elizabeth Fontham, Pelayo Correa, Joy Mele

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Data were analyzed from a case-control interview study of malignant mesothelioma in Louisiana, which gathered information on usual diet and on lifetime occupational exposure to asbestos. Thirty-seven patients with malignant mesothelioma of the pleura (n = 32) or peritoneum (n= 5) were matched to controls according to age, sex, race, and factors related to case ascertainment (hospital and date of diagnosis, or parish and date of death). Twenty-one of the 37 cases were judged by masked occupational review to have been exposed to asbestos (57%), compared to seven of 37 controls (19%). Seven additional cases and 10 additional controls had occupational histories suggestive of asbestos exposure. With regard to usual diet before illness, cases reported less frequent consumption of homegrown produce (p = 0.005), cruciferous vegetables (p = 0.005), and all vegetables combined (p = 0.09) than did the controls. An estimate of usual carotene intake was also significantly lower in cases (p = 0.03). Dose-dependent reductions in risk were seen with increasing consumption of vegetables, especially cruciferous vegetables (p for trend = 0.013). These associations were not explained by differences in asbestos exposure as measured by the occupational review. The results indicate that consumption of vegetables or some vegetable-related constituent may have a protective effect on developing mesothelioma.

Original languageEnglish (US)
Pages (from-to)2911-2915
Number of pages5
JournalCancer Research
Volume48
Issue number10
StatePublished - May 1988

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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