Case report: ABO discrepancy due to vancomycin complicating a transfusion reaction investigation

D. M. Gilbert, Ronald Domen

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A 3-year-old patient with acute myelogenous leukemia developed fever and chills during transfusion of packed red cells. A preliminary workup suggested that a group AB donor unit had been issued to a Group A patient. However, a discrepancy between the ABO group of the original donor unit segment (A) and blood taken from the IV tubing (AB) and the patient's pre- and posttransfusion samples (A and AB, respectively) suggested another reason for the weak reactivity of some samples with anti-B. The patient's chart revealed that vancomycin, reported to be a cause of non-immune agglutination of red cells, had been injected into the IV tubing one hour prior to transfusion. Further testing confirmed that the patient's febrile response to transfusion was consistent with a nonhemolytic transfusion reaction and was unrelated to the drug-induced, pseudo ABO problem.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
Issue number4
Publication statusPublished - Dec 1 1989


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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