Case report: Abo discrepancy due to vancomycin complicating a transfusion reaction investigation

D. M. Gilbert, Ronald Domen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A 3-year-oldpatient with acute myelogenous leukemia developed fever and chills during transfusion of packed red cells. A preliminary workup suggested that a group AB donor unit had been issued to a Group A patient. However, a discrepancy between the ABO group of the original donor unit segment (A) and blood taken from the IV tubing (AB) and the patient's pre- and posttransfusion samples (A and AB, respectively) suggested mother reason for the weak reactivity of some samples with anti-8. The patient's chart revealedthatvancomycin, reportedto be a cause of non-immune agglutination of red cells, had been injected into the IV tubing one hour prior to transfusion. Further testing confirmed that the patient's febrileresponse to transfusion was consistent with a nonhemolytic transfusion raction and was unrelatedto the drug-induced, pseudo ABO problem.

Original languageEnglish (US)
Pages (from-to)119-120
Number of pages2
JournalImmunohematology
Volume5
Issue number4
DOIs
StatePublished - Dec 1989

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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