Case report and review of literature: Leptomeningeal relapse in epithelial ovarian cancer

Ali M. Khalil, Bassem I. Yamout, Samer D. Tabbal, Ziad M.K. Salem, Adnan M. Mroueh

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The diagnosis of leptomeningeal relapse in a patient with epithelial ovarian cancer was confirmed by the presence of malignant ovarian cells in the cerebrospinal fluid. There was no clinical evidence of tumor spread elsewhere. Therapy, including intrathecal methotrexate and whole-brain irradiation led to transient clinical improvement. International literature review revealed only 13 other cases of leptomeningeal carcinomatosis in epithelial ovarian cancer; all died within 15 months following the diagnosis of leptomeningeal spread.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalGynecologic Oncology
Volume54
Issue number2
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynecology

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