Case report of sinus histiocytosis with massive cervical lymphadenopathy, Rosai-Dorfman disease in a child with serological findings of a recent Ebstein-Barr virus infection

S. Culic, D. Kuljis, M. Marinkovic, I. Kuzmic, M. Scukanec-Spoljar, D. Budimir, V. Culic, D. Primorac

Research output: Contribution to journalArticle

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Abstract

We report a case of a very rare and benign disease, sinus histiocytosis with massive lymphadenopathy (SHML) in a child with serological findings of a EBV infection. A 4-year-old-boy was admitted with a huge bilateral solid and painless enlargement of the cervical lymph nodes and symptoms of mononucleosis. Histopathology and immunohistochemistry confirmed the diagnosis of SHML. Immunohistochemistry of Epstein-Barr virus expression in lymph nodes (EBNA2, ZEBRA, and LMP EBV) was carried out and the slides were negative. Epstein-Barr virus serological findings were as follows: IgM ANTI-VCA negative, IgG ANTI-VCA positive 180 Au/mL, IgM ANTI-EBNA negative and IgG ANTI-EBNA positive 250 Au/mL, IgG ANTI-EA negative. Peripheral blood smear microscopy revealed virus transformed lymphocytes. Following corticosteroid (methylprednisolon) therapy the boy reached a stable remission.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalPaediatria Croatica
Volume44
Issue number3
StatePublished - Jan 1 2000

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Sinus Histiocytosis
Virus Diseases
Human Herpesvirus 4
Immunoglobulin G
Immunoglobulin M
Lymph Nodes
Immunohistochemistry
Epstein-Barr Virus Infections
Methylprednisolone
Rare Diseases
Microscopy
Adrenal Cortex Hormones
Lymphocytes
Viruses
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Culic, S., Kuljis, D., Marinkovic, M., Kuzmic, I., Scukanec-Spoljar, M., Budimir, D., ... Primorac, D. (2000). Case report of sinus histiocytosis with massive cervical lymphadenopathy, Rosai-Dorfman disease in a child with serological findings of a recent Ebstein-Barr virus infection. Paediatria Croatica, 44(3), 125-128.
Culic, S. ; Kuljis, D. ; Marinkovic, M. ; Kuzmic, I. ; Scukanec-Spoljar, M. ; Budimir, D. ; Culic, V. ; Primorac, D. / Case report of sinus histiocytosis with massive cervical lymphadenopathy, Rosai-Dorfman disease in a child with serological findings of a recent Ebstein-Barr virus infection. In: Paediatria Croatica. 2000 ; Vol. 44, No. 3. pp. 125-128.
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abstract = "We report a case of a very rare and benign disease, sinus histiocytosis with massive lymphadenopathy (SHML) in a child with serological findings of a EBV infection. A 4-year-old-boy was admitted with a huge bilateral solid and painless enlargement of the cervical lymph nodes and symptoms of mononucleosis. Histopathology and immunohistochemistry confirmed the diagnosis of SHML. Immunohistochemistry of Epstein-Barr virus expression in lymph nodes (EBNA2, ZEBRA, and LMP EBV) was carried out and the slides were negative. Epstein-Barr virus serological findings were as follows: IgM ANTI-VCA negative, IgG ANTI-VCA positive 180 Au/mL, IgM ANTI-EBNA negative and IgG ANTI-EBNA positive 250 Au/mL, IgG ANTI-EA negative. Peripheral blood smear microscopy revealed virus transformed lymphocytes. Following corticosteroid (methylprednisolon) therapy the boy reached a stable remission.",
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Culic, S, Kuljis, D, Marinkovic, M, Kuzmic, I, Scukanec-Spoljar, M, Budimir, D, Culic, V & Primorac, D 2000, 'Case report of sinus histiocytosis with massive cervical lymphadenopathy, Rosai-Dorfman disease in a child with serological findings of a recent Ebstein-Barr virus infection', Paediatria Croatica, vol. 44, no. 3, pp. 125-128.

Case report of sinus histiocytosis with massive cervical lymphadenopathy, Rosai-Dorfman disease in a child with serological findings of a recent Ebstein-Barr virus infection. / Culic, S.; Kuljis, D.; Marinkovic, M.; Kuzmic, I.; Scukanec-Spoljar, M.; Budimir, D.; Culic, V.; Primorac, D.

In: Paediatria Croatica, Vol. 44, No. 3, 01.01.2000, p. 125-128.

Research output: Contribution to journalArticle

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AU - Culic, S.

AU - Kuljis, D.

AU - Marinkovic, M.

AU - Kuzmic, I.

AU - Scukanec-Spoljar, M.

AU - Budimir, D.

AU - Culic, V.

AU - Primorac, D.

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N2 - We report a case of a very rare and benign disease, sinus histiocytosis with massive lymphadenopathy (SHML) in a child with serological findings of a EBV infection. A 4-year-old-boy was admitted with a huge bilateral solid and painless enlargement of the cervical lymph nodes and symptoms of mononucleosis. Histopathology and immunohistochemistry confirmed the diagnosis of SHML. Immunohistochemistry of Epstein-Barr virus expression in lymph nodes (EBNA2, ZEBRA, and LMP EBV) was carried out and the slides were negative. Epstein-Barr virus serological findings were as follows: IgM ANTI-VCA negative, IgG ANTI-VCA positive 180 Au/mL, IgM ANTI-EBNA negative and IgG ANTI-EBNA positive 250 Au/mL, IgG ANTI-EA negative. Peripheral blood smear microscopy revealed virus transformed lymphocytes. Following corticosteroid (methylprednisolon) therapy the boy reached a stable remission.

AB - We report a case of a very rare and benign disease, sinus histiocytosis with massive lymphadenopathy (SHML) in a child with serological findings of a EBV infection. A 4-year-old-boy was admitted with a huge bilateral solid and painless enlargement of the cervical lymph nodes and symptoms of mononucleosis. Histopathology and immunohistochemistry confirmed the diagnosis of SHML. Immunohistochemistry of Epstein-Barr virus expression in lymph nodes (EBNA2, ZEBRA, and LMP EBV) was carried out and the slides were negative. Epstein-Barr virus serological findings were as follows: IgM ANTI-VCA negative, IgG ANTI-VCA positive 180 Au/mL, IgM ANTI-EBNA negative and IgG ANTI-EBNA positive 250 Au/mL, IgG ANTI-EA negative. Peripheral blood smear microscopy revealed virus transformed lymphocytes. Following corticosteroid (methylprednisolon) therapy the boy reached a stable remission.

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