Case report: Pathologic long bone fracture in a patient with systemic mastocytosis

Joseph J. King, Eileen A. Crawford, O. Hans Iwenofu, Edward Fox

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Systemic mastocytosis is characterized by clonal proliferation of mast cells, which cause disease by accumulating in various organs and releasing their chemical products into tissues. We highlight a patient with systemic mastocytosis that caused a pathologic femur fracture in a 63-year-old man with minimal trauma. The typical presentation of bone involvement is a combination of mixed sclerotic and osteolytic lesions, but this patient also had osteopenia. Although bone involvement is common in patients with systemic mastocytosis, pathologic fractures outside the vertebral column are rare. The patient was treated with intramedullary fixation of his femur and retained adequate fixation at the time of his death 7 months postoperatively. We review the literature on pathologic fractures outside the vertebral column in patients with systemic mastocytosis.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalClinical Orthopaedics and Related Research
Issue number459
DOIs
StatePublished - Jan 1 2007

Fingerprint

Systemic Mastocytosis
Bone Fractures
Spontaneous Fractures
Femur
Spine
Bone and Bones
Metabolic Bone Diseases
Mast Cells
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

King, Joseph J. ; Crawford, Eileen A. ; Iwenofu, O. Hans ; Fox, Edward. / Case report : Pathologic long bone fracture in a patient with systemic mastocytosis. In: Clinical Orthopaedics and Related Research. 2007 ; No. 459. pp. 263-269.
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Case report : Pathologic long bone fracture in a patient with systemic mastocytosis. / King, Joseph J.; Crawford, Eileen A.; Iwenofu, O. Hans; Fox, Edward.

In: Clinical Orthopaedics and Related Research, No. 459, 01.01.2007, p. 263-269.

Research output: Contribution to journalArticle

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