Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

Stephen Benkovic, A. D. Napper, R. A. Lerner

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

Original languageEnglish (US)
Pages (from-to)5355-5358
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number15
DOIs
StatePublished - Jan 1 1988

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Lactones
Catalysis
Amides
Amines
Antibodies

All Science Journal Classification (ASJC) codes

  • General

Cite this

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Catalysis of a stereospecific bimolecular amide synthesis by an antibody. / Benkovic, Stephen; Napper, A. D.; Lerner, R. A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 15, 01.01.1988, p. 5355-5358.

Research output: Contribution to journalArticle

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