Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

S. J. Benkovic; A. D. Napper; R. A. Lerner

doi:10.1073/pnas.85.15.5355

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

S. J. Benkovic, A. D. Napper, R. A. Lerner

Chemistry

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7 Scopus citations

Abstract

We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

Original language	English (US)
Pages (from-to)	5355-5358
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	85
Issue number	15
DOIs	https://doi.org/10.1073/pnas.85.15.5355
State	Published - Aug 1988

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10.1073/pnas.85.15.5355

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title = "Catalysis of a stereospecific bimolecular amide synthesis by an antibody.",

abstract = "We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.",

author = "Benkovic, {S. J.} and Napper, {A. D.} and Lerner, {R. A.}",

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AU - Napper, A. D.

AU - Lerner, R. A.

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N2 - We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

AB - We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

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JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

Abstract

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