Catalytic antibodies with lipase activity and R or S substrate selectivity

Kim D. Janda, Stephen Benkovic, Richard A. Lerner

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (103 to 105) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalScience
Volume244
Issue number4903
DOIs
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • General

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