Catatonia. II. Treatment with lorazepam and electroconvulsive therapy

G. Bush, M. Fink, G. Petrides, F. Dowling, A. Francis

Research output: Contribution to journalArticle

263 Citations (Scopus)

Abstract

Case material and retrospective studies support the use of both lorazepam and ECT in treating catatonia, but few prospective investigations exist and none employ quantitative monitoring of response. In this study we test their efficacy in an open, prospective protocol, and define a 'lorazepam test' with predictive value for treatment. Twenty-eight patients with catatonia were treated systematically with parenteral and/or oral lorazepam for up to 5 days, and with ECT if lorazepam failed. Outcome was monitored quantitatively during the treatment phase with the Bush-Francis Catatonia Rating Scale (BFCRS). In 16 of 21 patients (76%) who received a complete trial of lorazepam (11 with initial intravenous challenge), catatonic signs resolved. A positive response to an initial parenteral challenge predicted final lorazepam response, as did length of catatonic symptoms prior to treatment. Neither demographic variables nor severity of catatonia predicted response to lorazepam. Four patients failing lorazepam responded promptly to ECT. It is concluded that lorazepam and ECT are effective treatments for catatonia. The rating scale has predictive value and displays sensitivity to change in clinical status.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalActa Psychiatrica Scandinavica
Volume93
Issue number2
DOIs
StatePublished - Jan 1 1996

Fingerprint

Catatonia
Lorazepam
Electroconvulsive Therapy
Therapeutics
Predictive Value of Tests
Retrospective Studies
Demography

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Bush, G. ; Fink, M. ; Petrides, G. ; Dowling, F. ; Francis, A. / Catatonia. II. Treatment with lorazepam and electroconvulsive therapy. In: Acta Psychiatrica Scandinavica. 1996 ; Vol. 93, No. 2. pp. 137-143.
@article{fb85d714dc57496f94d80b46454326a0,
title = "Catatonia. II. Treatment with lorazepam and electroconvulsive therapy",
abstract = "Case material and retrospective studies support the use of both lorazepam and ECT in treating catatonia, but few prospective investigations exist and none employ quantitative monitoring of response. In this study we test their efficacy in an open, prospective protocol, and define a 'lorazepam test' with predictive value for treatment. Twenty-eight patients with catatonia were treated systematically with parenteral and/or oral lorazepam for up to 5 days, and with ECT if lorazepam failed. Outcome was monitored quantitatively during the treatment phase with the Bush-Francis Catatonia Rating Scale (BFCRS). In 16 of 21 patients (76{\%}) who received a complete trial of lorazepam (11 with initial intravenous challenge), catatonic signs resolved. A positive response to an initial parenteral challenge predicted final lorazepam response, as did length of catatonic symptoms prior to treatment. Neither demographic variables nor severity of catatonia predicted response to lorazepam. Four patients failing lorazepam responded promptly to ECT. It is concluded that lorazepam and ECT are effective treatments for catatonia. The rating scale has predictive value and displays sensitivity to change in clinical status.",
author = "G. Bush and M. Fink and G. Petrides and F. Dowling and A. Francis",
year = "1996",
month = "1",
day = "1",
doi = "10.1111/j.1600-0447.1996.tb09815.x",
language = "English (US)",
volume = "93",
pages = "137--143",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "2",

}

Catatonia. II. Treatment with lorazepam and electroconvulsive therapy. / Bush, G.; Fink, M.; Petrides, G.; Dowling, F.; Francis, A.

In: Acta Psychiatrica Scandinavica, Vol. 93, No. 2, 01.01.1996, p. 137-143.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Catatonia. II. Treatment with lorazepam and electroconvulsive therapy

AU - Bush, G.

AU - Fink, M.

AU - Petrides, G.

AU - Dowling, F.

AU - Francis, A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Case material and retrospective studies support the use of both lorazepam and ECT in treating catatonia, but few prospective investigations exist and none employ quantitative monitoring of response. In this study we test their efficacy in an open, prospective protocol, and define a 'lorazepam test' with predictive value for treatment. Twenty-eight patients with catatonia were treated systematically with parenteral and/or oral lorazepam for up to 5 days, and with ECT if lorazepam failed. Outcome was monitored quantitatively during the treatment phase with the Bush-Francis Catatonia Rating Scale (BFCRS). In 16 of 21 patients (76%) who received a complete trial of lorazepam (11 with initial intravenous challenge), catatonic signs resolved. A positive response to an initial parenteral challenge predicted final lorazepam response, as did length of catatonic symptoms prior to treatment. Neither demographic variables nor severity of catatonia predicted response to lorazepam. Four patients failing lorazepam responded promptly to ECT. It is concluded that lorazepam and ECT are effective treatments for catatonia. The rating scale has predictive value and displays sensitivity to change in clinical status.

AB - Case material and retrospective studies support the use of both lorazepam and ECT in treating catatonia, but few prospective investigations exist and none employ quantitative monitoring of response. In this study we test their efficacy in an open, prospective protocol, and define a 'lorazepam test' with predictive value for treatment. Twenty-eight patients with catatonia were treated systematically with parenteral and/or oral lorazepam for up to 5 days, and with ECT if lorazepam failed. Outcome was monitored quantitatively during the treatment phase with the Bush-Francis Catatonia Rating Scale (BFCRS). In 16 of 21 patients (76%) who received a complete trial of lorazepam (11 with initial intravenous challenge), catatonic signs resolved. A positive response to an initial parenteral challenge predicted final lorazepam response, as did length of catatonic symptoms prior to treatment. Neither demographic variables nor severity of catatonia predicted response to lorazepam. Four patients failing lorazepam responded promptly to ECT. It is concluded that lorazepam and ECT are effective treatments for catatonia. The rating scale has predictive value and displays sensitivity to change in clinical status.

UR - http://www.scopus.com/inward/record.url?scp=0029995097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029995097&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.1996.tb09815.x

DO - 10.1111/j.1600-0447.1996.tb09815.x

M3 - Article

C2 - 8686484

AN - SCOPUS:0029995097

VL - 93

SP - 137

EP - 143

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 2

ER -