Catechol-bearing polymerie nanoparticles for antioxidant therapy

Urara Hasegawa, Masaki Moriyama, Hiroshi Uyama, André J. Van Der Vlies, Stéphanie Metzger, Martin Ehrbar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polymeric nanoparticles having redox-active catechol moieties, a common structural motif found in naturally-occurring antioxidants, were developed. We synthesized an amphiphilic catechol-bearing polymer that self-assembled to form nanoparticles with a diameter of 126 nm. The nanoparticles showed enhanced ROS-scavenging activity compared to the small catecholic compound dopamine. Furthermore, the nanoparticles inhibited ROS-mediated angiogenesis as shown by the endothelial cell tube formation assay and the chicken chorioallantoic membrane (CAM) assay.

Original languageEnglish (US)
Title of host publicationNanomaterials in Translational Medicine
EditorsC. Xu, Z. Gu, S. Mitragoti
PublisherMaterials Research Society
Pages13-18
Number of pages6
ISBN (Electronic)9781510826502
DOIs
StatePublished - 2015
Event2015 MRS Spring Meeting - San Francisco, United States
Duration: Apr 6 2015Apr 10 2015

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1797
ISSN (Print)0272-9172

Other

Other2015 MRS Spring Meeting
CountryUnited States
CitySan Francisco
Period4/6/154/10/15

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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