Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits

S. T. Chao, Curtis John Omiecinski, M. J. Namkung, S. D. Nelson, B. H. Dvorchik, M. R. Juchau

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Abstract

Placental and fetal tissues obtained from humans, monkeys, rats and rabbits contained monooxygenases capable of catalyzing the formation of catechol estrogens. Treatments of pregnant rats with phenobarbital, Aroclor 1254, or 3-methylcholanthrene each increased measured rates of catechol estrogen formation in placentas, fetal brains and fetal livers, while other rat tissues exhibited either increased or decreased activity. Treatment of pregnant rabbits with Arocolor 1254 produced an increase in catechol estrogen formation in all fetal tissues studied and in the maternal liver and kidney. Catechol estrogen formation in placental microsomes of macaque monkeys (Macaca arctoides) was generally less than that observed in human placental microsomes. Human placentas obtained from smokers exhibited enhanced catechol estrogen formation and this activity appeared to be highly correlated with placental aryl hydrocarbon hydroxylase activity. The data suggested that environmental factors may affect the aromatic hydroxylation of β-estradiol and benzo[a]pyrene in a similar fashion in placental tissues and that the enzyme systems involved may be under similar regulatory control.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalDevelopmental Pharmacology and Therapeutics
Volume2
Issue number1
StatePublished - 1981

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Catechol Estrogens
Macaca
Fetus
Rabbits
Microsomes
Placenta
Haplorhini
Chlorodiphenyl (54% Chlorine)
Aryl Hydrocarbon Hydroxylases
Methylcholanthrene
Benzo(a)pyrene
Liver
Hydroxylation
Phenobarbital
Mixed Function Oxygenases
Estradiol
Mothers
Kidney
Brain
Enzymes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chao, S. T., Omiecinski, C. J., Namkung, M. J., Nelson, S. D., Dvorchik, B. H., & Juchau, M. R. (1981). Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits. Developmental Pharmacology and Therapeutics, 2(1), 1-16.
Chao, S. T. ; Omiecinski, Curtis John ; Namkung, M. J. ; Nelson, S. D. ; Dvorchik, B. H. ; Juchau, M. R. / Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits. In: Developmental Pharmacology and Therapeutics. 1981 ; Vol. 2, No. 1. pp. 1-16.
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Chao, ST, Omiecinski, CJ, Namkung, MJ, Nelson, SD, Dvorchik, BH & Juchau, MR 1981, 'Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits', Developmental Pharmacology and Therapeutics, vol. 2, no. 1, pp. 1-16.

Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits. / Chao, S. T.; Omiecinski, Curtis John; Namkung, M. J.; Nelson, S. D.; Dvorchik, B. H.; Juchau, M. R.

In: Developmental Pharmacology and Therapeutics, Vol. 2, No. 1, 1981, p. 1-16.

Research output: Contribution to journalArticle

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