Causal relationship between diet-induced gut microbiota changes and diabetes: A novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes

Kumar Ganesan, Sookja Kim Chung, Jairam Vanamala, Baojun Xu

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (Science Direct, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut’s microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.

Original languageEnglish (US)
Article number3720
JournalInternational journal of molecular sciences
Volume19
Issue number12
DOIs
StatePublished - Dec 2018

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diets
Transplants
Nutrition
Medical problems
disorders
Diet
Inflammation
transplantation
Dysbiosis
bacteria
health
Butyrates
incidence
Microbiota
Autoimmunity
Type 1 Diabetes Mellitus
modulation
PubMed
Autoimmune Diseases
Libraries

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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abstract = "The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (Science Direct, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut’s microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.",
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Causal relationship between diet-induced gut microbiota changes and diabetes : A novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes. / Ganesan, Kumar; Chung, Sookja Kim; Vanamala, Jairam; Xu, Baojun.

In: International journal of molecular sciences, Vol. 19, No. 12, 3720, 12.2018.

Research output: Contribution to journalReview article

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