Caveat Emptor: Single nucleotide polymorphism reporting in pharmacogenomics

Izel Tekin, Kent E. Vrana

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

While it is arguably the most comprehensive source of genetic information, the NCBI's dbSNP database (National Center for Biotechnology Information database of single nucleotide polymorphisms; http://www.ncbi.nlm.nih.gov/ projects/SNP/) is imperfect. In this commentary, we highlight the issues surrounding this database, while considering the great importance and utility of this resource for those in the pharmacology and pharmacogenomics communities. We describe our experience with the information in this database as a cautionary tale for those who will utilize such information in the future. We also discuss several measures that could render it more reliable.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalPharmacology
Volume92
Issue number5-6
DOIs
StatePublished - Jan 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology

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