CCR10 is important for the development of skin-specific γδT cells by regulating their migration and location

Yan Jin, Mingcan Xia, Allen Sun, Christina M. Saylor, Na Xiong

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Unlike conventional αβ T cells, which preferentially reside in secondary lymphoid organs for adaptive immune responses, various subsets of unconventional T cells, such as the γδ T cells with innate properties, preferentially reside in epithelial tissues as the first line of defense. However, mechanisms underlying their tissue-specific development are not well understood. We report in this paper that among different thymic T cell subsets fetal thymic precursors of the prototypic skin intraepithelial Vγ3+ T lymphocytes (sIELs) were selected to display a unique pattern of homing molecules, including a high level of CCR10 expression that was important for their development into sIELs. In fetal CCR10-knockout mice, the Vγ3+ sIEL precursors developed normally in the thymus but were defective in migrating into the skin. Although the earlier defect in skin-seeding by sIEL precursors was partially compensated for by their normal expansion in the skin of adult CCR10-knockout mice, the Vγ3+ sIELs displayed abnormal morphology and increasingly accumulated in the dermal region of the skin. These findings provide definite evidence that CCR10 is important in sIEL development by regulating the migration of sIEL precursors and their maintenance in proper regions of the skin and support the notion that unique homing properties of different thymic T cell subsets play an important role in their peripheral location.

Original languageEnglish (US)
Pages (from-to)5723-5731
Number of pages9
JournalJournal of Immunology
Volume185
Issue number10
DOIs
StatePublished - Nov 15 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'CCR10 is important for the development of skin-specific γδT cells by regulating their migration and location'. Together they form a unique fingerprint.

Cite this