TY - JOUR
T1 - CD8+CD103+ regulatory T cells in spontaneous tolerance of liver allografts
AU - Lu, Ling
AU - Yu, Yue
AU - Li, Guoqiang
AU - Pu, Liyong
AU - Zhang, Feng
AU - Zheng, Songguo
AU - Wang, Xuehao
PY - 2009/5
Y1 - 2009/5
N2 - It has been shown that rat liver allografts between certain inbred major histocompatibility complex (MHC) disparate strains are accepted spontaneously, and regulatory T cells (Tregs) have been suggested to play a role in the spontaneous liver tolerance. CD8+CD103+ T cells bear the phenotypes of effector cells, and they are implicated in allograft destruction. Here we provide evidence that CD8+CD103+ T cells possess regulatory function and may contribute to prevent liver allograft rejection. We show that the expression of CD103 in the CD8+ T cells was increased in spontaneous liver grafts tolerant recipients. We further show that CD8+CD103- T cells can also upregulate the expression of CD103 and Foxp3 after stimulation with alloantigen or TGF-β in vitro, and the CD8+CD103+ T cells acquired regulatory properties. The suppressive function of the alloantigen or TGF-β conditioned CD8+CD103+ T cells was cell-cell contact dependent. These results imply that liver-specific factor(s) would be involved in the generation of CD8+CD103+ Tregs that contribute to spontaneous liver allografts tolerance.
AB - It has been shown that rat liver allografts between certain inbred major histocompatibility complex (MHC) disparate strains are accepted spontaneously, and regulatory T cells (Tregs) have been suggested to play a role in the spontaneous liver tolerance. CD8+CD103+ T cells bear the phenotypes of effector cells, and they are implicated in allograft destruction. Here we provide evidence that CD8+CD103+ T cells possess regulatory function and may contribute to prevent liver allograft rejection. We show that the expression of CD103 in the CD8+ T cells was increased in spontaneous liver grafts tolerant recipients. We further show that CD8+CD103- T cells can also upregulate the expression of CD103 and Foxp3 after stimulation with alloantigen or TGF-β in vitro, and the CD8+CD103+ T cells acquired regulatory properties. The suppressive function of the alloantigen or TGF-β conditioned CD8+CD103+ T cells was cell-cell contact dependent. These results imply that liver-specific factor(s) would be involved in the generation of CD8+CD103+ Tregs that contribute to spontaneous liver allografts tolerance.
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U2 - 10.1016/j.intimp.2009.01.021
DO - 10.1016/j.intimp.2009.01.021
M3 - Article
C2 - 19539566
AN - SCOPUS:63549098516
VL - 9
SP - 546
EP - 548
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 5
ER -