CD94-NKG2A receptors regulate antiviral CD8+ T cell responses

Janice M. Moser, James Gibbs, Peter E. Jensen, Aron Lukacher

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

CD8+ T lymphocytes mediate immunosurveillance against persistent virus infections and virus-induced neoplasia. Polyoma virus, a highly oncogenic natural mouse DNA virus, establishes persistent infection, but only a few mice are highly susceptible to tumors induced by the virus. Mature antiviral CD8+ T cells expand in tumor-susceptible mice, but their cytotoxic effector activity is nonfunctional in vivo. Here we show that the natural killer cell inhibitory receptor, CD94-NKG2A, is up-regulated by antiviral CD8+ T cells during acute polyoma infection and is responsible for down-regulating their antigen-specific cytotoxicity during both viral clearance and virus-induced oncogenesis.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalNature Immunology
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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