CD4 +CD25 +Foxp3 regulatoryTcells and vascular dysfunction in hypertension

Modar Kassan, Andrea Wecker, Philip Kadowitz, Mohamed Trebak, Khalid Matrougui

Research output: Contribution to journalReview article

32 Scopus citations


Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

Original languageEnglish (US)
Pages (from-to)1939-1943
Number of pages5
JournalJournal of hypertension
Issue number10
StatePublished - Oct 1 2013


All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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