Cell deformation and adhesion kinetics in leukocyte rolling

Xiaoxiao Lei, Cheng Dong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A two-dimensional theoretical model was developed to examine how shear flow-induced cell deformation interacted with cell adhesion kinetics in regulating leukocyte rolling. It was found that shear flow-induced cell deformation not only affected fluid energy input to the rolling cells and the viscous cytoplasm dissipation, it also greatly influenced adhesion energy dissipation by changing cell-substrate contact area. Adhesion kinetics also influenced cell rolling velocity through the adhesion energy dissipation.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages257-258
Number of pages2
Volume42
ISBN (Print)0791816117
Publication statusPublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Lei, X., & Dong, C. (1999). Cell deformation and adhesion kinetics in leukocyte rolling. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 42, pp. 257-258). ASME.