As part of an ongoing study on iron status and immune function, to collect baseline data and determine effects of aging on immunocompetence we examined CMI and bactericidal function in a cohort of older (O, n=12, age: 65-85y) versus younger (Y, n=21, age: 20-40y) women. Subjects were apparently healthy, free from inflammation, and generally well-nourished based on clinical chemistry and hematological tests. Our preliminary results suggest that although % lymphocytes in both age groups was normal, it was 23% higher in O vs Y (p<0.05). Specifically, total T- (CDS+) and T-helper (CD4+) subsets were higher (27 and 30% respectively) in O vs Y (p<0.05). The proliferation response of T cells to stimulation with phytohemagglutinin (PHA) was 55% lower in O vs Y (p<0.05), while no difference was seen with Concanavalin A. Natural killer (NK) cell activity expressed as % specific target cell lysis per NK cell was 41% lower in older women (p<0.05). The oxidative burst capacity of granulocytes and monocytes was unaffected with age (p>0.05). Based on our preliminary examination, we conclude that immunosenescence was limited to certain cell function markers (T-cell proliferation response to PHA, and NK cell activity) while other immune parameters were not compromised with age.
|Original language||English (US)|
|State||Published - Mar 20 1998|
All Science Journal Classification (ASJC) codes
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology