Cell surface molecules in basal cell carcinomas

Mary Pentel, Klaus Helm, Mary M. Maloney

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background.: The factors determining a basal cell carcinoma's (BCC's) growth pattern and invasive potential are not known. In other tumors it has been shown recently that the expression of cellular adhesion molecules may determine a tumor's invasive and metastatic potential. Integrins, cell surface molecules important in cell stroma interactions, are present on BCCs and may help regulate the tumor's growth pattern. Objective.: We compared the expression of cellular adhesion molecules α2 integrin, β1 integrin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), leukocyte function antigen 1a (LFA-1a), and E-selectin in different histological subtypes of basal cell carcinomas. Methods.: BCCs were obtained from patients undergoing Mohs surgery. The BCCs were classified as nodular, micronodular, mixed, infiltrative, and basosquamous types and stained using an avidin-biotin-immunoperoxidase technique with antibodies against α2 integrin, β1 integrin, ICAM, LFA-1a, VCAM-1, and E-selectin. Results.: BCCs expressed α2 and β1 integrin, but no significant differences in the amount or pattern of expression was seen in the different histologic subtypes. Conclusion.: The expression of integrins by BCCs by binding to the surrounding stroma may limit BCC's growth; however, their expression does not appear to correlate with their histological pattern.

Original languageEnglish (US)
Pages (from-to)858-861
Number of pages4
JournalDermatologic Surgery
Volume21
Issue number10
DOIs
StatePublished - Dec 1 1995

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Basal Cell Carcinoma
Integrins
E-Selectin
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
HLA Antigens
Growth
Mohs Surgery
Neoplasms
Avidin
Biotin
Immunoenzyme Techniques
Cell Communication
Antibodies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

Pentel, Mary ; Helm, Klaus ; Maloney, Mary M. / Cell surface molecules in basal cell carcinomas. In: Dermatologic Surgery. 1995 ; Vol. 21, No. 10. pp. 858-861.
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Cell surface molecules in basal cell carcinomas. / Pentel, Mary; Helm, Klaus; Maloney, Mary M.

In: Dermatologic Surgery, Vol. 21, No. 10, 01.12.1995, p. 858-861.

Research output: Contribution to journalArticle

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