Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis

D. M. Levin, E. A. Ottesen, Herbert Reynolds, C. H. Kirkpatrick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A rat model of Trichinella spiralis gut infection was used to observe the sequence of developing cellular immunity in Peyer's patches and other lymphoid tissues. Whereas cellular reactivity (lymphocyte blastogenesis) for worm antigens was evident in mesenteric lymph nodes draining the gastro intestinal tract within 3 days after infection, Peyer's patch lymphocytes developed maximal reactivity 2 to 3 weeks later at the same time as the spleen and other lymphoid tissues. Furthermore, the immune reactivity found in Peyer's patches was only transient. Thus, in this parasitic gut infection, the Peyer's patch lymphoid tissue does not appear to be the first site of cellular responsiveness but rather to acquire cellular reactivity only when other lymphoid elements in the infected host have also acquired similar antigen induced reactivity.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalInfection and Immunity
Volume13
Issue number1
StatePublished - Dec 1 1976

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Trichinella spiralis
Peyer's Patches
Cellular Immunity
Lymphoid Tissue
Lymphocytes
Antigens
Parasitic Diseases
Lymphocyte Activation
Infection
Spleen
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Levin, D. M., Ottesen, E. A., Reynolds, H., & Kirkpatrick, C. H. (1976). Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis. Infection and Immunity, 13(1), 27-30.
Levin, D. M. ; Ottesen, E. A. ; Reynolds, Herbert ; Kirkpatrick, C. H. / Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis. In: Infection and Immunity. 1976 ; Vol. 13, No. 1. pp. 27-30.
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Levin, DM, Ottesen, EA, Reynolds, H & Kirkpatrick, CH 1976, 'Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis', Infection and Immunity, vol. 13, no. 1, pp. 27-30.

Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis. / Levin, D. M.; Ottesen, E. A.; Reynolds, Herbert; Kirkpatrick, C. H.

In: Infection and Immunity, Vol. 13, No. 1, 01.12.1976, p. 27-30.

Research output: Contribution to journalArticle

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Levin DM, Ottesen EA, Reynolds H, Kirkpatrick CH. Cellular immunity in Peyer's patches of rats infected with Trichinella spiralis. Infection and Immunity. 1976 Dec 1;13(1):27-30.