Central carbon metabolism of Plasmodium parasites

Kellen L. Olszewski, Manuel Llinás

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The central role of metabolic perturbation to the pathology of malaria, the promise of antimetabolites as antimalarial drugs and a basic scientific interest in understanding this fascinating example of highly divergent microbial metabolism has spurred a major and concerted research effort towards elucidating the metabolic network of the Plasmodium parasites. Central carbon metabolism, broadly comprising the flow of carbon from nutrients into biomass, has been a particular focus due to clear and early indications that it plays an essential role in this network. Decades of painstaking efforts have significantly clarified our understanding of these pathways of carbon flux, and this foundational knowledge, coupled with the advent of advanced analytical technologies, have set the stage for the development of a holistic, network-level model of plasmodial carbon metabolism. In this review we summarize the current state of knowledge regarding central carbon metabolism and suggest future avenues of research. We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalMolecular and biochemical parasitology
Volume175
Issue number2
DOIs
StatePublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Central carbon metabolism of Plasmodium parasites'. Together they form a unique fingerprint.

Cite this