Central osmotic regulation of sympathetic nerve activity

G. M. Toney, Q. H. Chen, M. J. Cato, Sean Stocker

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Aim: In this review, we will focus on the central neural mechanisms that couple osmotic perturbations to changes in sympathetic nerve discharge, and the possible impact these actions have in cardiovascular diseases such as arterial hypertension and congestive heart failure. Results: Changes in extracellular fluid osmolality lead to specific regulatory responses in defence of body fluid and cardiovascular homeostasis. Systemic hyperosmolality is well known to stimulate thirst and the release of antidiuretic hormone. These responses are largely due to osmosensing neurones in the forebrain lamina terminalis and hypothalamus and are critical elements in a control system that operates to restore body fluid osmolality. An equally important, but less characterized, target of central osmoregulatory processes is the sympathetic nervous system. Conclusion: Understanding the neurobiology of sympathetic responses to changes in osmolality has important implications for body fluid and cardiovascular physiology. By stabilizing osmolality, vascular volume is preserved and thereby relatively normal levels of cardiac output and arterial pressure are maintained.

Original languageEnglish (US)
Pages (from-to)43-55
Number of pages13
JournalActa Physiologica Scandinavica
Volume177
Issue number1
DOIs
StatePublished - Jan 18 2003

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Osmolar Concentration
Body Fluids
Hypothalamus
Cardiovascular Physiological Phenomena
Thirst
Neurobiology
Sympathetic Nervous System
Extracellular Fluid
Prosencephalon
Vasopressins
Cardiac Output
Blood Vessels
Arterial Pressure
Homeostasis
Cardiovascular Diseases
Heart Failure
Hypertension
Neurons

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Toney, G. M. ; Chen, Q. H. ; Cato, M. J. ; Stocker, Sean. / Central osmotic regulation of sympathetic nerve activity. In: Acta Physiologica Scandinavica. 2003 ; Vol. 177, No. 1. pp. 43-55.
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Central osmotic regulation of sympathetic nerve activity. / Toney, G. M.; Chen, Q. H.; Cato, M. J.; Stocker, Sean.

In: Acta Physiologica Scandinavica, Vol. 177, No. 1, 18.01.2003, p. 43-55.

Research output: Contribution to journalArticle

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