Central precocious puberty: An overview of diagnosis, treatment, and outcome

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Abstract

Therapy with GnRH analogues is the treatment of choice for progressive CPP. Because the improvement of adult height involves only a few centimeters, except in patients who have a very early and robust onset of CPP, therapy generally should not be given in an effort to improve height alone. Therapy is effective in restoring a prepubertal hormonal milieu followed by cessation of pubertal growth and development. Pubertal development, for social and psychologic reasons, can be delayed until a more appropriate age. Progressive CPP can be identified by a clear progression of pubertal changes and an acceleration of growth rates and skeletal maturity, with pubertal hormone levels and responses to GnRH stimulation. A timely institution of therapy would be within a few months of onset once progression can be documented and before height potential is lost. With adequate timing of therapy for progressive CPP, genetically expected adult height can be achieved.

Original languageEnglish (US)
Pages (from-to)901-918
Number of pages18
JournalEndocrinology and Metabolism Clinics of North America
Volume28
Issue number4
DOIs
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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