TY - JOUR
T1 - Central precocious puberty
T2 - An overview of diagnosis, treatment, and outcome
AU - Lee, P. A.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Therapy with GnRH analogues is the treatment of choice for progressive CPP. Because the improvement of adult height involves only a few centimeters, except in patients who have a very early and robust onset of CPP, therapy generally should not be given in an effort to improve height alone. Therapy is effective in restoring a prepubertal hormonal milieu followed by cessation of pubertal growth and development. Pubertal development, for social and psychologic reasons, can be delayed until a more appropriate age. Progressive CPP can be identified by a clear progression of pubertal changes and an acceleration of growth rates and skeletal maturity, with pubertal hormone levels and responses to GnRH stimulation. A timely institution of therapy would be within a few months of onset once progression can be documented and before height potential is lost. With adequate timing of therapy for progressive CPP, genetically expected adult height can be achieved.
AB - Therapy with GnRH analogues is the treatment of choice for progressive CPP. Because the improvement of adult height involves only a few centimeters, except in patients who have a very early and robust onset of CPP, therapy generally should not be given in an effort to improve height alone. Therapy is effective in restoring a prepubertal hormonal milieu followed by cessation of pubertal growth and development. Pubertal development, for social and psychologic reasons, can be delayed until a more appropriate age. Progressive CPP can be identified by a clear progression of pubertal changes and an acceleration of growth rates and skeletal maturity, with pubertal hormone levels and responses to GnRH stimulation. A timely institution of therapy would be within a few months of onset once progression can be documented and before height potential is lost. With adequate timing of therapy for progressive CPP, genetically expected adult height can be achieved.
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U2 - 10.1016/S0889-8529(05)70108-0
DO - 10.1016/S0889-8529(05)70108-0
M3 - Article
C2 - 10609126
AN - SCOPUS:0032761556
VL - 28
SP - 901
EP - 918
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 4
ER -