Cerebral Blood Flow Velocities in Extremely Low Birth Weight Infants with Hypotension and Infants with Normal Blood Pressure

Marla H. Lightburn, C. Heath Gauss, D. Keith Williams, Jeffrey Kaiser

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. Study design: In this case control study, CBF velocity (with Doppler ultrasound scanning), Pco2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP ≤ gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 ± 140 g, 24.2 ± 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test. Results: The groups did not differ significantly in gestational age, birth weight, race, sex, Pco2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg). Conclusion: Despite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.

Original languageEnglish (US)
Pages (from-to)824-828
Number of pages5
JournalJournal of Pediatrics
Volume154
Issue number6
DOIs
StatePublished - Jun 1 2009

Fingerprint

Cerebrovascular Circulation
Extremely Low Birth Weight Infant
Blood Flow Velocity
Hypotension
Arterial Pressure
Blood Pressure
Gestational Age
Birth Weight
Doppler Ultrasonography
Apgar Score
Critical Care
Nonparametric Statistics
Case-Control Studies
Dopamine
Hemodynamics
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{936110f0ec2c4917bc1524bc536b8ad9,
title = "Cerebral Blood Flow Velocities in Extremely Low Birth Weight Infants with Hypotension and Infants with Normal Blood Pressure",
abstract = "Objective: To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. Study design: In this case control study, CBF velocity (with Doppler ultrasound scanning), Pco2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP ≤ gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 ± 140 g, 24.2 ± 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test. Results: The groups did not differ significantly in gestational age, birth weight, race, sex, Pco2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg). Conclusion: Despite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.",
author = "Lightburn, {Marla H.} and Gauss, {C. Heath} and Williams, {D. Keith} and Jeffrey Kaiser",
year = "2009",
month = "6",
day = "1",
doi = "10.1016/j.jpeds.2009.01.006",
language = "English (US)",
volume = "154",
pages = "824--828",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6",

}

Cerebral Blood Flow Velocities in Extremely Low Birth Weight Infants with Hypotension and Infants with Normal Blood Pressure. / Lightburn, Marla H.; Gauss, C. Heath; Williams, D. Keith; Kaiser, Jeffrey.

In: Journal of Pediatrics, Vol. 154, No. 6, 01.06.2009, p. 824-828.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cerebral Blood Flow Velocities in Extremely Low Birth Weight Infants with Hypotension and Infants with Normal Blood Pressure

AU - Lightburn, Marla H.

AU - Gauss, C. Heath

AU - Williams, D. Keith

AU - Kaiser, Jeffrey

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Objective: To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. Study design: In this case control study, CBF velocity (with Doppler ultrasound scanning), Pco2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP ≤ gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 ± 140 g, 24.2 ± 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test. Results: The groups did not differ significantly in gestational age, birth weight, race, sex, Pco2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg). Conclusion: Despite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.

AB - Objective: To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. Study design: In this case control study, CBF velocity (with Doppler ultrasound scanning), Pco2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP ≤ gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 ± 140 g, 24.2 ± 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test. Results: The groups did not differ significantly in gestational age, birth weight, race, sex, Pco2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg). Conclusion: Despite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.

UR - http://www.scopus.com/inward/record.url?scp=67349262020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349262020&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2009.01.006

DO - 10.1016/j.jpeds.2009.01.006

M3 - Article

VL - 154

SP - 824

EP - 828

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 6

ER -