Cerebral oligemic hypoxia and iron toxicity in the mesolimbic system of rats

Christine Marcelle Heim, M. Melzacka, W. Kolasiewicz, T. Jaros, M. Sieklucka, W. Wesemann, K. H. Sontag

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

60 min of bilateral clamping of the carotid arteries (BCCA) in pentobarbital anaesthetized adult Wistar rats increases the lipid peroxidation in hippocampal tissue as estimated four weeks later. 1.5 μg FeCl3 in 2 μl buffer injected unilaterally in the ventrolateral striatum enforced the effect when applicated one week after the BCCA treatmeut. During ageing, the explorative and locomotor behaviour of BCCA rats decreased earlier than the behaviour activities of the controls. These activities show no more changes 9 months after surgery but the BCCA treated rats were more sensitive to 2 mg/kg apomorphine s.c., demonstrated by the distance travelled during 1 hour of habituation in a new environment. BCCA treated rats rotate in response to apomorphine after an intrastriatal and ventrolateral injection of 0.3 μg FeCl3 15 and 14 weeks, respectively, after BCCA and iron instead of 1.5 μg after iron injection alone. Transient BCCA leads to a dramatical increase of released DA. We assume, therefore, that during the autooxidation of released DA, free radicals trigger the increase of lipid peroxidation. Predamaged tissue due to increased lipid peroxidation reacts to very small amounts of iron and iron seems to be more toxic in such cerebral tissue.

Original languageEnglish (US)
Pages (from-to)165-173
Number of pages9
JournalJournal of Neural Transmission, Supplement
Issue number46
StatePublished - Dec 1 1995

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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