Cerebral oxygenation during locomotion is modulated by respiration

Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak, Patrick J. Drew

Research output: Contribution to journalArticle

Abstract

In the brain, increased neural activity is correlated with increases of cerebral blood flow and tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving animal remains unclear. We investigated to what extent cerebral oxygenation varies during locomotion. We measured oxygen levels in the cortex of awake, head-fixed mice during locomotion using polarography, spectroscopy, and two-photon phosphorescence lifetime measurements of oxygen sensors. We find that locomotion significantly and globally increases cerebral oxygenation, specifically in areas involved in locomotion, as well as in the frontal cortex and the olfactory bulb. The oxygenation increase persists when neural activity and functional hyperemia are blocked, occurred both in the tissue and in arteries feeding the brain, and is tightly correlated with respiration rate and the phase of respiration cycle. Thus, breathing rate is a key modulator of cerebral oxygenation and should be monitored during hemodynamic imaging, such as in BOLD fMRI.

Original languageEnglish (US)
Article number5515
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Oxygenation
locomotion
oxygenation
respiration
Locomotion
Respiration
Oxygen
cortexes
Cerebrovascular Circulation
brain
Luminescent Measurements
Polarography
Brain
oxygen
Olfactory Bulb
polarography
Tissue
Hyperemia
Frontal Lobe
Polarographic analysis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Zhang, Q., Roche, M., Gheres, K. W., Chaigneau, E., Kedarasetti, R. T., Haselden, W. D., ... Drew, P. J. (2019). Cerebral oxygenation during locomotion is modulated by respiration. Nature communications, 10(1), [5515]. https://doi.org/10.1038/s41467-019-13523-5
Zhang, Qingguang ; Roche, Morgane ; Gheres, Kyle W. ; Chaigneau, Emmanuelle ; Kedarasetti, Ravi T. ; Haselden, William D. ; Charpak, Serge ; Drew, Patrick J. / Cerebral oxygenation during locomotion is modulated by respiration. In: Nature communications. 2019 ; Vol. 10, No. 1.
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Zhang, Q, Roche, M, Gheres, KW, Chaigneau, E, Kedarasetti, RT, Haselden, WD, Charpak, S & Drew, PJ 2019, 'Cerebral oxygenation during locomotion is modulated by respiration', Nature communications, vol. 10, no. 1, 5515. https://doi.org/10.1038/s41467-019-13523-5

Cerebral oxygenation during locomotion is modulated by respiration. / Zhang, Qingguang; Roche, Morgane; Gheres, Kyle W.; Chaigneau, Emmanuelle; Kedarasetti, Ravi T.; Haselden, William D.; Charpak, Serge; Drew, Patrick J.

In: Nature communications, Vol. 10, No. 1, 5515, 01.12.2019.

Research output: Contribution to journalArticle

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Zhang Q, Roche M, Gheres KW, Chaigneau E, Kedarasetti RT, Haselden WD et al. Cerebral oxygenation during locomotion is modulated by respiration. Nature communications. 2019 Dec 1;10(1). 5515. https://doi.org/10.1038/s41467-019-13523-5