Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Manuela Marron, Paolo Boffetta, Zuo Feng Zhang, David Zaridze, Victor Wünsch-Filho, Deborah M. Winn, Qingyi Wei, Renato Talamini, Neonila Szeszenia-Dabrowska, Erich M. Sturgis, Elaine Smith, Stephen M. Schwartz, Peter Rudnai, Mark P. Purdue, Andrew F. Olshan, Jose Eluf-Neto, Joshua Muscat, Hal Morgenstern, Ana Menezes, Michael McCleanElena Matos, Ioan Nicolae Mates, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Karl Kelsey, Rolando Herrero, Richard B. Hayes, Silvia Franceschi, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Luigino Dal Maso, Maria Paula Curado, Gabriella Cadoni, Chu Chen, Xavier Castellsague, Stefania Boccia, Simone Benhamou, Gilles Ferro, Julien Berthiller, Paul Brennan, Henrik Møller, Mia Hashibe

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Background: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

Original languageEnglish (US)
Pages (from-to)182-196
Number of pages15
JournalInternational journal of epidemiology
Volume39
Issue number1
DOIs
StatePublished - Oct 5 2009

All Science Journal Classification (ASJC) codes

  • Epidemiology

Fingerprint Dive into the research topics of 'Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk'. Together they form a unique fingerprint.

  • Cite this

    Marron, M., Boffetta, P., Zhang, Z. F., Zaridze, D., Wünsch-Filho, V., Winn, D. M., Wei, Q., Talamini, R., Szeszenia-Dabrowska, N., Sturgis, E. M., Smith, E., Schwartz, S. M., Rudnai, P., Purdue, M. P., Olshan, A. F., Eluf-Neto, J., Muscat, J., Morgenstern, H., Menezes, A., ... Hashibe, M. (2009). Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. International journal of epidemiology, 39(1), 182-196. https://doi.org/10.1093/ije/dyp291