Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Manuela Marron, Paolo Boffetta, Zuo Feng Zhang, David Zaridze, Victor Wünsch-Filho, Deborah M. Winn, Qingyi Wei, Renato Talamini, Neonila Szeszenia-Dabrowska, Erich M. Sturgis, Elaine Smith, Stephen M. Schwartz, Peter Rudnai, Mark P. Purdue, Andrew F. Olshan, Jose Eluf-Neto, Joshua Muscat, Hal Morgenstern, Ana Menezes, Michael McClean & 26 others Elena Matos, Ioan Nicolae Mates, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Karl Kelsey, Rolando Herrero, Richard B. Hayes, Silvia Franceschi, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Luigino Dal Maso, Maria Paula Curado, Gabriella Cadoni, Chu Chen, Xavier Castellsague, Stefania Boccia, Simone Benhamou, Gilles Ferro, Julien Berthiller, Paul Brennan, Henrik Møller, Mia Hashibe

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Background: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

Original languageEnglish (US)
Pages (from-to)182-196
Number of pages15
JournalInternational journal of epidemiology
Volume39
Issue number1
DOIs
StatePublished - Oct 5 2009

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Head and Neck Neoplasms
Alcohol Drinking
Smoking
Smoking Cessation
Odds Ratio
Drinking
Confidence Intervals
Risk Reduction Behavior
Logistic Models
Alcohols
Tobacco Use Cessation
Habits
Tobacco
Case-Control Studies
Epidemiology

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Marron, M., Boffetta, P., Zhang, Z. F., Zaridze, D., Wünsch-Filho, V., Winn, D. M., ... Hashibe, M. (2009). Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. International journal of epidemiology, 39(1), 182-196. https://doi.org/10.1093/ije/dyp291
Marron, Manuela ; Boffetta, Paolo ; Zhang, Zuo Feng ; Zaridze, David ; Wünsch-Filho, Victor ; Winn, Deborah M. ; Wei, Qingyi ; Talamini, Renato ; Szeszenia-Dabrowska, Neonila ; Sturgis, Erich M. ; Smith, Elaine ; Schwartz, Stephen M. ; Rudnai, Peter ; Purdue, Mark P. ; Olshan, Andrew F. ; Eluf-Neto, Jose ; Muscat, Joshua ; Morgenstern, Hal ; Menezes, Ana ; McClean, Michael ; Matos, Elena ; Mates, Ioan Nicolae ; Lissowska, Jolanta ; Levi, Fabio ; Lazarus, Philip ; La Vecchia, Carlo ; Koifman, Sergio ; Kelsey, Karl ; Herrero, Rolando ; Hayes, Richard B. ; Franceschi, Silvia ; Fernandez, Leticia ; Fabianova, Eleonora ; Daudt, Alexander W. ; Dal Maso, Luigino ; Curado, Maria Paula ; Cadoni, Gabriella ; Chen, Chu ; Castellsague, Xavier ; Boccia, Stefania ; Benhamou, Simone ; Ferro, Gilles ; Berthiller, Julien ; Brennan, Paul ; Møller, Henrik ; Hashibe, Mia. / Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. In: International journal of epidemiology. 2009 ; Vol. 39, No. 1. pp. 182-196.
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abstract = "Background: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.",
author = "Manuela Marron and Paolo Boffetta and Zhang, {Zuo Feng} and David Zaridze and Victor W{\"u}nsch-Filho and Winn, {Deborah M.} and Qingyi Wei and Renato Talamini and Neonila Szeszenia-Dabrowska and Sturgis, {Erich M.} and Elaine Smith and Schwartz, {Stephen M.} and Peter Rudnai and Purdue, {Mark P.} and Olshan, {Andrew F.} and Jose Eluf-Neto and Joshua Muscat and Hal Morgenstern and Ana Menezes and Michael McClean and Elena Matos and Mates, {Ioan Nicolae} and Jolanta Lissowska and Fabio Levi and Philip Lazarus and {La Vecchia}, Carlo and Sergio Koifman and Karl Kelsey and Rolando Herrero and Hayes, {Richard B.} and Silvia Franceschi and Leticia Fernandez and Eleonora Fabianova and Daudt, {Alexander W.} and {Dal Maso}, Luigino and Curado, {Maria Paula} and Gabriella Cadoni and Chu Chen and Xavier Castellsague and Stefania Boccia and Simone Benhamou and Gilles Ferro and Julien Berthiller and Paul Brennan and Henrik M{\o}ller and Mia Hashibe",
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Marron, M, Boffetta, P, Zhang, ZF, Zaridze, D, Wünsch-Filho, V, Winn, DM, Wei, Q, Talamini, R, Szeszenia-Dabrowska, N, Sturgis, EM, Smith, E, Schwartz, SM, Rudnai, P, Purdue, MP, Olshan, AF, Eluf-Neto, J, Muscat, J, Morgenstern, H, Menezes, A, McClean, M, Matos, E, Mates, IN, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Kelsey, K, Herrero, R, Hayes, RB, Franceschi, S, Fernandez, L, Fabianova, E, Daudt, AW, Dal Maso, L, Curado, MP, Cadoni, G, Chen, C, Castellsague, X, Boccia, S, Benhamou, S, Ferro, G, Berthiller, J, Brennan, P, Møller, H & Hashibe, M 2009, 'Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk', International journal of epidemiology, vol. 39, no. 1, pp. 182-196. https://doi.org/10.1093/ije/dyp291

Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. / Marron, Manuela; Boffetta, Paolo; Zhang, Zuo Feng; Zaridze, David; Wünsch-Filho, Victor; Winn, Deborah M.; Wei, Qingyi; Talamini, Renato; Szeszenia-Dabrowska, Neonila; Sturgis, Erich M.; Smith, Elaine; Schwartz, Stephen M.; Rudnai, Peter; Purdue, Mark P.; Olshan, Andrew F.; Eluf-Neto, Jose; Muscat, Joshua; Morgenstern, Hal; Menezes, Ana; McClean, Michael; Matos, Elena; Mates, Ioan Nicolae; Lissowska, Jolanta; Levi, Fabio; Lazarus, Philip; La Vecchia, Carlo; Koifman, Sergio; Kelsey, Karl; Herrero, Rolando; Hayes, Richard B.; Franceschi, Silvia; Fernandez, Leticia; Fabianova, Eleonora; Daudt, Alexander W.; Dal Maso, Luigino; Curado, Maria Paula; Cadoni, Gabriella; Chen, Chu; Castellsague, Xavier; Boccia, Stefania; Benhamou, Simone; Ferro, Gilles; Berthiller, Julien; Brennan, Paul; Møller, Henrik; Hashibe, Mia.

In: International journal of epidemiology, Vol. 39, No. 1, 05.10.2009, p. 182-196.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

AU - Marron, Manuela

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Zaridze, David

AU - Wünsch-Filho, Victor

AU - Winn, Deborah M.

AU - Wei, Qingyi

AU - Talamini, Renato

AU - Szeszenia-Dabrowska, Neonila

AU - Sturgis, Erich M.

AU - Smith, Elaine

AU - Schwartz, Stephen M.

AU - Rudnai, Peter

AU - Purdue, Mark P.

AU - Olshan, Andrew F.

AU - Eluf-Neto, Jose

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Menezes, Ana

AU - McClean, Michael

AU - Matos, Elena

AU - Mates, Ioan Nicolae

AU - Lissowska, Jolanta

AU - Levi, Fabio

AU - Lazarus, Philip

AU - La Vecchia, Carlo

AU - Koifman, Sergio

AU - Kelsey, Karl

AU - Herrero, Rolando

AU - Hayes, Richard B.

AU - Franceschi, Silvia

AU - Fernandez, Leticia

AU - Fabianova, Eleonora

AU - Daudt, Alexander W.

AU - Dal Maso, Luigino

AU - Curado, Maria Paula

AU - Cadoni, Gabriella

AU - Chen, Chu

AU - Castellsague, Xavier

AU - Boccia, Stefania

AU - Benhamou, Simone

AU - Ferro, Gilles

AU - Berthiller, Julien

AU - Brennan, Paul

AU - Møller, Henrik

AU - Hashibe, Mia

PY - 2009/10/5

Y1 - 2009/10/5

N2 - Background: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

AB - Background: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

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U2 - 10.1093/ije/dyp291

DO - 10.1093/ije/dyp291

M3 - Article

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SP - 182

EP - 196

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

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