Cessation of drinking following intracranial injections of angiotensin in the rat

Barbara J. Rolls, Barbara P. Jones

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Abstract

Injection of angiotensin amide into the preoptic area is known to elicit drinking in rats that are in water balance. 2 experiments were conducted with a total of 15 male hooded rats. When Ss were injected with 10 ng. angiotensin and access to water was delayed for varying times, the dipsogenic effect of angiotensin lasted for 60-90 min. When access to water was not delayed, Ss stopped drinking after 8.5 min., indicating that the ingestion of water is satiating. When Ss were offered isotonic saline, they stopped drinking 11 min. after injection, indicating that satiation or inhibition of angiotensin-induced thirst can also occur when there are no osmotic changes. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of Comparative and Physiological Psychology
Volume80
Issue number1
DOIs
Publication statusPublished - Jul 1 1972

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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