@article{2e888dfa5e3f4b8491be7c70bb3ad553,
title = "Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward",
abstract = "Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.",
author = "{for the Investigators of the ADAPT Study} and Bell, {Michael J.} and Adelson, {P. David} and Wisniewski, {Stephen R.} and Shruti Agrawal and Sarah Mahoney and Deepak Gupta and John Beca and Laura Loftis and Kevin Morris and Lauren Piper and Anthony Slater and Karen Walson and Tellen Bennett and Todd Kilbaugh and O{\textquoteright}Meara, {A. M.Iqbal} and Nathan Dean and Chima, {Ranjit S.} and Katherine Biagas and Enno Wildschut and Mark Peters and Kerri LaRovere and Joan Balcells and Courtney Robertson and Shira Gertz and Akash Deep and Sian Cooper and Mark Wainwright and Sarah Murphy and John Kuluz and Warwick Butt and Nicole O{\textquoteright}Brien and Thomas, {Neal J.} and Sandra Buttram and Simon Erickson and Samuel, {J. Mahil} and Rachel Agbeko and Richard Edwards and Ramakrishnan, {Kesava Ananth} and Margaret Winkler and Santiago Borasino and Joanne Natale and Christopher Giza and Mary Hilfiker and David Shellington and Anthony Figaji and Elizabeth Newell and Edward Truemper and Robert Clark and Kit Newth and Nadeem Shafi",
note = "Funding Information: Conflict of interest The authors have no conflicts of interest to report except for the grant funding from NIH. Funding Information: Funding Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01 NS081041. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany.",
year = "2017",
month = oct,
day = "1",
doi = "10.1007/s00381-017-3530-y",
language = "English (US)",
volume = "33",
pages = "1663--1667",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer Verlag",
number = "10",
}