Challenges in bio-fabrication of organoid cultures

Weijie Peng, Pallab Datta, Yang Wu, Madhuri Dey, Bugra Ayan, Amer Dababneh, Ibrahim T. Ozbolat

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Three-dimensional (3D) organoids have shown advantages in cell culture over traditional two-dimensional (2D) culture, and have great potential in various applications of tissue engineering. However, there are limitations in current organoid fabrication technologies, such as uncontrolled size, poor reproductively, and inadequate complexity of organoids. In this chapter, we present the existing techniques and discuss the major challenges for 3D organoid biofabrication. Future perspectives on organoid bioprinting are also discussed, where bioprinting technologies are expected to make a major contribution in organoid fabrication, such as realizing mass production and constructing complex heterotypic tissues, and thus further advance the translational application of organoids in tissue engineering and regenerative medicine as well drug testing and pharmaceutics.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages53-71
Number of pages19
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1107
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Peng, W., Datta, P., Wu, Y., Dey, M., Ayan, B., Dababneh, A., & Ozbolat, I. T. (2018). Challenges in bio-fabrication of organoid cultures. In Advances in Experimental Medicine and Biology (pp. 53-71). (Advances in Experimental Medicine and Biology; Vol. 1107). Springer New York LLC. https://doi.org/10.1007/5584_2018_216