Challenges in herbal research: A randomized clinical trial to assess blinding with ginger

Suzanna M. Zick, Amy Blume, Daniel Normolle, Mack Ruffin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To assess methods to blind study participants to encapsulated ginger (Zingiber officinale). Design: A randomized double-blind placebo controlled trial. Subjects: Eighty healthy male and female volunteers. Outcome measures: Whether participants can accurately determine if they receive a ginger or placebo capsule and a bottle filled with ginger or placebo capsules. Results: Forty-two subjects correctly identified the capsule they received. Of those who received placebo, over 82% correctly identified their capsule. Only 22.5% of those who received ginger correctly identified their capsule. The likelihood of guessing ginger between the groups was statistically similar (p < 0.01). 65% correctly guessed which bottle they had received (p = 0.0073). Participants receiving the bottle filled with ginger capsules successfully identified their bottle 75% of the time (p = 0.0016) compared to the 55% of the placebo group (p = 0.5). Conclusions: Volunteers cannot determine which type of individual capsule they receive but can distinguish a bottle filled with ginger capsules.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalComplementary Therapies in Medicine
Volume13
Issue number2
DOIs
StatePublished - Jun 1 2005

Fingerprint

Ginger
Capsules
Randomized Controlled Trials
Research
Placebos
Volunteers
Healthy Volunteers
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Complementary and Manual Therapy
  • Complementary and alternative medicine
  • Advanced and Specialized Nursing

Cite this

Zick, Suzanna M. ; Blume, Amy ; Normolle, Daniel ; Ruffin, Mack. / Challenges in herbal research : A randomized clinical trial to assess blinding with ginger. In: Complementary Therapies in Medicine. 2005 ; Vol. 13, No. 2. pp. 101-106.
@article{a2fe4c7b6f3d4bca8e057333a3d9477a,
title = "Challenges in herbal research: A randomized clinical trial to assess blinding with ginger",
abstract = "Objective: To assess methods to blind study participants to encapsulated ginger (Zingiber officinale). Design: A randomized double-blind placebo controlled trial. Subjects: Eighty healthy male and female volunteers. Outcome measures: Whether participants can accurately determine if they receive a ginger or placebo capsule and a bottle filled with ginger or placebo capsules. Results: Forty-two subjects correctly identified the capsule they received. Of those who received placebo, over 82{\%} correctly identified their capsule. Only 22.5{\%} of those who received ginger correctly identified their capsule. The likelihood of guessing ginger between the groups was statistically similar (p < 0.01). 65{\%} correctly guessed which bottle they had received (p = 0.0073). Participants receiving the bottle filled with ginger capsules successfully identified their bottle 75{\%} of the time (p = 0.0016) compared to the 55{\%} of the placebo group (p = 0.5). Conclusions: Volunteers cannot determine which type of individual capsule they receive but can distinguish a bottle filled with ginger capsules.",
author = "Zick, {Suzanna M.} and Amy Blume and Daniel Normolle and Mack Ruffin",
year = "2005",
month = "6",
day = "1",
doi = "10.1016/j.ctim.2005.04.001",
language = "English (US)",
volume = "13",
pages = "101--106",
journal = "Complementary Therapies in Medicine",
issn = "0965-2299",
publisher = "Churchill Livingstone",
number = "2",

}

Challenges in herbal research : A randomized clinical trial to assess blinding with ginger. / Zick, Suzanna M.; Blume, Amy; Normolle, Daniel; Ruffin, Mack.

In: Complementary Therapies in Medicine, Vol. 13, No. 2, 01.06.2005, p. 101-106.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Challenges in herbal research

T2 - A randomized clinical trial to assess blinding with ginger

AU - Zick, Suzanna M.

AU - Blume, Amy

AU - Normolle, Daniel

AU - Ruffin, Mack

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Objective: To assess methods to blind study participants to encapsulated ginger (Zingiber officinale). Design: A randomized double-blind placebo controlled trial. Subjects: Eighty healthy male and female volunteers. Outcome measures: Whether participants can accurately determine if they receive a ginger or placebo capsule and a bottle filled with ginger or placebo capsules. Results: Forty-two subjects correctly identified the capsule they received. Of those who received placebo, over 82% correctly identified their capsule. Only 22.5% of those who received ginger correctly identified their capsule. The likelihood of guessing ginger between the groups was statistically similar (p < 0.01). 65% correctly guessed which bottle they had received (p = 0.0073). Participants receiving the bottle filled with ginger capsules successfully identified their bottle 75% of the time (p = 0.0016) compared to the 55% of the placebo group (p = 0.5). Conclusions: Volunteers cannot determine which type of individual capsule they receive but can distinguish a bottle filled with ginger capsules.

AB - Objective: To assess methods to blind study participants to encapsulated ginger (Zingiber officinale). Design: A randomized double-blind placebo controlled trial. Subjects: Eighty healthy male and female volunteers. Outcome measures: Whether participants can accurately determine if they receive a ginger or placebo capsule and a bottle filled with ginger or placebo capsules. Results: Forty-two subjects correctly identified the capsule they received. Of those who received placebo, over 82% correctly identified their capsule. Only 22.5% of those who received ginger correctly identified their capsule. The likelihood of guessing ginger between the groups was statistically similar (p < 0.01). 65% correctly guessed which bottle they had received (p = 0.0073). Participants receiving the bottle filled with ginger capsules successfully identified their bottle 75% of the time (p = 0.0016) compared to the 55% of the placebo group (p = 0.5). Conclusions: Volunteers cannot determine which type of individual capsule they receive but can distinguish a bottle filled with ginger capsules.

UR - http://www.scopus.com/inward/record.url?scp=22144491861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144491861&partnerID=8YFLogxK

U2 - 10.1016/j.ctim.2005.04.001

DO - 10.1016/j.ctim.2005.04.001

M3 - Article

C2 - 16036167

AN - SCOPUS:22144491861

VL - 13

SP - 101

EP - 106

JO - Complementary Therapies in Medicine

JF - Complementary Therapies in Medicine

SN - 0965-2299

IS - 2

ER -