Chance and necessity in the evolution of RNase P

Venkat Gopalan, Nayef Jarrous, Andrey S. Krasilnikov

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

RNase P catalyzes 5??-maturation of tRNAs in all three domains of life. This primary function is accomplished by either a ribozyme-centered ribonucleoprotein (RNP) or a protein-only variant (with one to three polypeptides). The large, multicomponent archaeal and eukaryotic RNase P RNPs appear disproportionate to the simplicity of their role in tRNA 5??-maturation, prompting the question of why the seemingly gratuitously complex RNP forms of RNase P were not replaced with simpler protein counterparts. Here, motivated by growing evidence, we consider the hypothesis that the large RNase P RNP was retained as a direct consequence of multiple roles played by its components in processes that are not related to the canonical RNase P function.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalRNA
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2018

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Ribonuclease P
Ribonucleoproteins
Transfer RNA
Catalytic RNA
Proteins
Peptides

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Cite this

Gopalan, Venkat ; Jarrous, Nayef ; Krasilnikov, Andrey S. / Chance and necessity in the evolution of RNase P. In: RNA. 2018 ; Vol. 24, No. 1. pp. 1-5.
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Chance and necessity in the evolution of RNase P. / Gopalan, Venkat; Jarrous, Nayef; Krasilnikov, Andrey S.

In: RNA, Vol. 24, No. 1, 01.01.2018, p. 1-5.

Research output: Contribution to journalArticle

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