TY - JOUR
T1 - Changes in Alcohol Use after Metabolic and Bariatric Surgery
T2 - Predictors and Mechanisms
AU - Ivezaj, Valentina
AU - Benoit, Stephen C.
AU - Davis, Jon
AU - Engel, Scott
AU - Lloret-Linares, Celia
AU - Mitchell, James E.
AU - Pepino, M. Yanina
AU - Rogers, Ann M.
AU - Steffen, Kristine
AU - Sogg, Stephanie
N1 - Funding Information:
Dr. Pepino reports a grant from the University of Illinois at Urbana-Champaign (NIH AA024103) and Dr. Mitchell reports funding from NIH.
Funding Information:
The authors would like to acknowledge the Radcliffe Institute for Advanced Study at Harvard University for funding the meeting, which contributed to this review. All authors received travel reimbursement to attend the Radcliffe meeting, from which this manuscript resulted. Outside the submitted work, Dr. Pepino and Dr. Mitchell report grants from the NIH and Dr. Steffen reports grants from Sanford Profile/NDSU, NIH, and Shire Pharmaceuticals.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Purpose of Review: This review synthesized the literature on predictors and mechanisms of post-bariatric alcohol problems, in order to guide future research on prevention and treatment targets. Recent Findings: Consistent evidence suggests an elevated risk of developing problems with alcohol following bariatric surgery. While there is a paucity of empirical data on predictors of problematic alcohol use after bariatric surgery, being male, a younger age, smoking, regular alcohol consumption, pre-surgical alcohol use disorder, and a lower sense of belonging have predicted alcohol misuse post-operatively. This review synthesizes potential mechanisms including specific bariatric surgical procedures, peptides and reinforcement/reward pathways, pharmacokinetics, and genetic influences. Finally, potential misperceptions regarding mechanisms are explored. Summary: Certain bariatric procedures elevate the risk of alcohol misuse post-operatively. Future research should serve to elucidate the complexities of reward signaling, genetically mediated mechanisms, and pharmacokinetics in relation to alcohol use across gender and developmental period by surgery type.
AB - Purpose of Review: This review synthesized the literature on predictors and mechanisms of post-bariatric alcohol problems, in order to guide future research on prevention and treatment targets. Recent Findings: Consistent evidence suggests an elevated risk of developing problems with alcohol following bariatric surgery. While there is a paucity of empirical data on predictors of problematic alcohol use after bariatric surgery, being male, a younger age, smoking, regular alcohol consumption, pre-surgical alcohol use disorder, and a lower sense of belonging have predicted alcohol misuse post-operatively. This review synthesizes potential mechanisms including specific bariatric surgical procedures, peptides and reinforcement/reward pathways, pharmacokinetics, and genetic influences. Finally, potential misperceptions regarding mechanisms are explored. Summary: Certain bariatric procedures elevate the risk of alcohol misuse post-operatively. Future research should serve to elucidate the complexities of reward signaling, genetically mediated mechanisms, and pharmacokinetics in relation to alcohol use across gender and developmental period by surgery type.
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U2 - 10.1007/s11920-019-1070-8
DO - 10.1007/s11920-019-1070-8
M3 - Review article
C2 - 31410716
AN - SCOPUS:85070707138
SN - 1523-3812
VL - 21
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
IS - 9
M1 - 85
ER -
