Changes in calcium distribution during therapeutic plasmapheresis

W. H. Roberts, Ronald Domen, M. I. Walters

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Observations of normal persons indicated that there was a net shift of serum calcium from the ionized and protein-bound fractions to the anion-bound fraction when these persons received citrate during donor plasmapheresis. To confirm these findings and to extend them to diseased persons, we measured total, ionized, and ultrafilterable Ca concentrations in 11 patients who were undergoing therapeutic plasmapheresis. Anticoagulation was achieved with anticoagulant citrate dextrose solution. Mean concentrations of total, ionized, and protein-bound Ca decreased, whereas the ultrafilterable and anion-bound fractions increased. Our results suggest that protein-bound Ca may be relatively labile and may help to maintain constant levels of ionized Ca. Also, the observed increase in the anion-bound Ca level with citrate infusion suggests a shift from the protein-bound and ionized Ca fractions to this pool.

Original languageEnglish (US)
Pages (from-to)881-883
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume108
Issue number11
StatePublished - Dec 1 1984

Fingerprint

Plasmapheresis
Citric Acid
Calcium
Anions
Proteins
Therapeutics
Anticoagulants
Tissue Donors
Glucose
Serum

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

@article{6f58c65a48d24d2f9f6954a616b22613,
title = "Changes in calcium distribution during therapeutic plasmapheresis",
abstract = "Observations of normal persons indicated that there was a net shift of serum calcium from the ionized and protein-bound fractions to the anion-bound fraction when these persons received citrate during donor plasmapheresis. To confirm these findings and to extend them to diseased persons, we measured total, ionized, and ultrafilterable Ca concentrations in 11 patients who were undergoing therapeutic plasmapheresis. Anticoagulation was achieved with anticoagulant citrate dextrose solution. Mean concentrations of total, ionized, and protein-bound Ca decreased, whereas the ultrafilterable and anion-bound fractions increased. Our results suggest that protein-bound Ca may be relatively labile and may help to maintain constant levels of ionized Ca. Also, the observed increase in the anion-bound Ca level with citrate infusion suggests a shift from the protein-bound and ionized Ca fractions to this pool.",
author = "Roberts, {W. H.} and Ronald Domen and Walters, {M. I.}",
year = "1984",
month = "12",
day = "1",
language = "English (US)",
volume = "108",
pages = "881--883",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "11",

}

Changes in calcium distribution during therapeutic plasmapheresis. / Roberts, W. H.; Domen, Ronald; Walters, M. I.

In: Archives of Pathology and Laboratory Medicine, Vol. 108, No. 11, 01.12.1984, p. 881-883.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in calcium distribution during therapeutic plasmapheresis

AU - Roberts, W. H.

AU - Domen, Ronald

AU - Walters, M. I.

PY - 1984/12/1

Y1 - 1984/12/1

N2 - Observations of normal persons indicated that there was a net shift of serum calcium from the ionized and protein-bound fractions to the anion-bound fraction when these persons received citrate during donor plasmapheresis. To confirm these findings and to extend them to diseased persons, we measured total, ionized, and ultrafilterable Ca concentrations in 11 patients who were undergoing therapeutic plasmapheresis. Anticoagulation was achieved with anticoagulant citrate dextrose solution. Mean concentrations of total, ionized, and protein-bound Ca decreased, whereas the ultrafilterable and anion-bound fractions increased. Our results suggest that protein-bound Ca may be relatively labile and may help to maintain constant levels of ionized Ca. Also, the observed increase in the anion-bound Ca level with citrate infusion suggests a shift from the protein-bound and ionized Ca fractions to this pool.

AB - Observations of normal persons indicated that there was a net shift of serum calcium from the ionized and protein-bound fractions to the anion-bound fraction when these persons received citrate during donor plasmapheresis. To confirm these findings and to extend them to diseased persons, we measured total, ionized, and ultrafilterable Ca concentrations in 11 patients who were undergoing therapeutic plasmapheresis. Anticoagulation was achieved with anticoagulant citrate dextrose solution. Mean concentrations of total, ionized, and protein-bound Ca decreased, whereas the ultrafilterable and anion-bound fractions increased. Our results suggest that protein-bound Ca may be relatively labile and may help to maintain constant levels of ionized Ca. Also, the observed increase in the anion-bound Ca level with citrate infusion suggests a shift from the protein-bound and ionized Ca fractions to this pool.

UR - http://www.scopus.com/inward/record.url?scp=0021751426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021751426&partnerID=8YFLogxK

M3 - Article

C2 - 6548363

AN - SCOPUS:0021751426

VL - 108

SP - 881

EP - 883

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 11

ER -