Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic

Gudrun S. Freidl, Henk Jan Van Den Ham, MacIej F. Boni, Erwin De Bruin, Marion P.G. Koopmans

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic-and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.

Original languageEnglish (US)
Article number20385
JournalScientific reports
Volume6
DOIs
StatePublished - Feb 8 2016

All Science Journal Classification (ASJC) codes

  • General

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