Changes in resting connectivity during recovery from severe traumatic brain injury

Frank Gerard Hillary, J. Slocomb, Everett Hills, N. M. Fitzpatrick, J. D. Medaglia, Jian-li Wang, David Good, G. R. Wylie

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

In the present study we investigate neural network changes after moderate and severe traumatic brain injury (TBI) through the use of resting state functional connectivity (RSFC) methods. Using blood oxygen level dependent functional MRI, we examined RSFC at 3 and 6. months following resolution of posttraumatic amnesia. The goal of this study was to examine how regional off-task connectivity changes during a critical period of recovery from significant neurological disruption. This was achieved by examining regional changes in the intrinsic, or "resting", BOLD fMRI signal in separate networks: 1) regions linked to goal-directed (or external-state) networks and 2) default mode (or internal-state) networks. Findings here demonstrate significantly increased resting connectivity internal-state networks in the TBI sample during the first 6. months following recovery. The most consistent finding was increased connectivity in both internal and external state networks to the insula and medial temporal regions during recovery. These findings were dissociable from repeat measurements in a matched healthy control sample.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalInternational Journal of Psychophysiology
Volume82
Issue number1
DOIs
StatePublished - Oct 1 2011

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Magnetic Resonance Imaging
Amnesia
Temporal Lobe
Oxygen
Traumatic Brain Injury
Critical Period (Psychology)

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

Cite this

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Changes in resting connectivity during recovery from severe traumatic brain injury. / Hillary, Frank Gerard; Slocomb, J.; Hills, Everett; Fitzpatrick, N. M.; Medaglia, J. D.; Wang, Jian-li; Good, David; Wylie, G. R.

In: International Journal of Psychophysiology, Vol. 82, No. 1, 01.10.2011, p. 115-123.

Research output: Contribution to journalArticle

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