Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia

Research output: Contribution to journalArticle

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Abstract

Acute respiratory complications occur frequently during the early phase of acute myeloid leukemia (AML) but information on the most severe form, acute respiratory distress syndrome (ARDS), is lacking. We retrospectively analyzed 280 patients with newly diagnosed AML in order to describe the incidence, risk factors and early mortality associated with ARDS within 15 d. Univariate and then multivariate analysis were performed. ARDS developed in 9% of patients and was associated with 64% day-30 mortality. White blood cell count on admission was an independent risk factor for ARDS (OR = 1.007, 95% CI = 1.001–1.012, p =.012) with a moderate prediction ability (AUC 0.704, p =.001). Other variables were associated with ARDS in univariate but not in multivariate analysis: body mass index (p =.06), transfusions (p =.001) and sepsis (p <.0001). Leukemia-specific complications and documented infections were the most frequent ARDS etiologies and were sometimes associated, with no clear distinctive temporal pattern.

Original languageEnglish (US)
Pages (from-to)2369-2376
Number of pages8
JournalLeukemia and Lymphoma
Volume59
Issue number10
DOIs
StatePublished - Oct 3 2018

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Adult Respiratory Distress Syndrome
Acute Myeloid Leukemia
Multivariate Analysis
Mortality
Leukocyte Count
Area Under Curve
Sepsis
Leukemia
Body Mass Index
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia",
abstract = "Acute respiratory complications occur frequently during the early phase of acute myeloid leukemia (AML) but information on the most severe form, acute respiratory distress syndrome (ARDS), is lacking. We retrospectively analyzed 280 patients with newly diagnosed AML in order to describe the incidence, risk factors and early mortality associated with ARDS within 15 d. Univariate and then multivariate analysis were performed. ARDS developed in 9{\%} of patients and was associated with 64{\%} day-30 mortality. White blood cell count on admission was an independent risk factor for ARDS (OR = 1.007, 95{\%} CI = 1.001–1.012, p =.012) with a moderate prediction ability (AUC 0.704, p =.001). Other variables were associated with ARDS in univariate but not in multivariate analysis: body mass index (p =.06), transfusions (p =.001) and sepsis (p <.0001). Leukemia-specific complications and documented infections were the most frequent ARDS etiologies and were sometimes associated, with no clear distinctive temporal pattern.",
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Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia. / Van De Louw, Andry; Desai, Ruchi J.; Zhu, Junjia; Claxton, David.

In: Leukemia and Lymphoma, Vol. 59, No. 10, 03.10.2018, p. 2369-2376.

Research output: Contribution to journalArticle

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AU - Van De Louw, Andry

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AB - Acute respiratory complications occur frequently during the early phase of acute myeloid leukemia (AML) but information on the most severe form, acute respiratory distress syndrome (ARDS), is lacking. We retrospectively analyzed 280 patients with newly diagnosed AML in order to describe the incidence, risk factors and early mortality associated with ARDS within 15 d. Univariate and then multivariate analysis were performed. ARDS developed in 9% of patients and was associated with 64% day-30 mortality. White blood cell count on admission was an independent risk factor for ARDS (OR = 1.007, 95% CI = 1.001–1.012, p =.012) with a moderate prediction ability (AUC 0.704, p =.001). Other variables were associated with ARDS in univariate but not in multivariate analysis: body mass index (p =.06), transfusions (p =.001) and sepsis (p <.0001). Leukemia-specific complications and documented infections were the most frequent ARDS etiologies and were sometimes associated, with no clear distinctive temporal pattern.

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